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Flashcards in Drug S.E. Deck (17)
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1

Atypical antipsychotics

Affect post synaptic D2
EPSE (less than typical)
Weight gain
Drowsiness
Sexual dysfunction
High prolactin
Arrythmias

2

Lithium

Weight gain
Hypothyroidism
GI disturbance
Diabetes insipidus
Intention tremor
Idiopathic intracranial HTN
Flattening of T wave

3

Olanzapine

Sedation and metabolic syndrome

4

Quetiapine

Long QTc

5

Risperidone

Metabolic derangement e.g. raised prolactin

6

Clozapine

Affects D1 and 4 and 5HT
Same as atypical but less likelihood of EPSE so can give at higher dose
Hypersalivation and other cholinergic effects (e.g. constipation)
Agranulocytosis - leukopenia, eosinophilia, leucocytosis → regular blood tests for WCC to prevent

7

Sodium Valproate Pregnancy

Neural Tube defect and dysmorphia

8

Clozapine monitoring

Weekly blood tests for 18 weeks, fortnightly for 1 year then monthly indefinitely

9

TCA

Dosulepin and amitriptyline most dangerous, so avoid giving to suicidal patients
Avoid in elderly as sensitive
Prolong QTc

10

Benzodiazepine

Increase frequency
FREnzodiazepine

11

Barbiturates

Increase duration
BarbitDURATes

12

Taking Triptans

Avoid SSRI

13

Venlafaxine

Avoid in HTN

14

Taking Warfarin / Heparin

Mirtazapine

15

Mirtazapine

Promotes weight gain and increases appetite

16

Mirtazapine

Promotes weight gain and increases appetite

17

SSRI

Drowsiness.
Nausea.
Dry mouth.
Insomnia.
Diarrhea.
Nervousness, agitation or restlessness.
Dizziness.
Sexual problems, such as reduced sexual desire or difficulty reaching orgasm or inability to maintain an erection (erectile dysfunction)