drug target

Question 1

What is a good drug target?

Answer 1

A good target has often a cavity-and a structure that is possible to block or activate
Specific expression for the target organ to avoid side effects
Specific function (avoid side effects)’
Accessible for the drug
High expression during the disease state
That compensatory mechanisms do not inactive the drug. Virus, address the parts that are not changed through mutations
The key node in the biological pathway, rate limiting step, cascade effect
Possible to address with low molecular weight substances

Question 2

Receptor enzymes

Answer 2

Transduction
•Activation cytoplasmic–Side enzyme
•Example: Tyrosine kinase

Question 3

Steroid receptors

Answer 3

Present in the cytoplasm or localized in the nucleus

•Ex. Glucocorticoid receptor