Drug Targets

Question 0

What is used to research the drug targets?

Answer 0

X-ray crystallography

Question 1

What are the six possible drug targets?

Answer 1

Enzymes, nucleic acid, nuclear receptors, ion channel receptors, plasma membrane receptors and transporters.

Question 2

Give and example of an enzymes target and drug?

Answer 2

Methotrexate and dihydrofolate reductase.
Saquinaur and HIV protease.
Ibuprofen/aspirin and COX.
Neostigmine and acetylcholine esterase.

Question 3

Give the two receptors for candasartan and salbutamol and what type they are?

Answer 3

ß2- adrenergic receptor and angiotensin AT-1 receptor. Both are plasma membrane receptors.

Question 4

Give two transporter examples?

Answer 4

Cocaine to dopamine and sertraline to serotonin.

Question 5

What does diazepam and glipizide target?

Answer 5

GABAa receptor and ATP sensitive K+ channels

Question 6

Give an example of a nucleic acid drug and it’s target?

Answer 6

Acitomycin and DNA.

Question 7

Give an example of a nuclear receptor drug and target?

Answer 7

Tamoxifen and oestrogen.

Question 8

Define a drug target?

Answer 8

Any biomolecule that binds a drug and induces a biological response