drug testing

Question 1

william withering

Answer 1

identify foxglove plant
trial on small group of patients with disease
trial on larger group- dosage
results recorded and published

Question 2

active ingredient in foxglove

Answer 2

digitalin

Question 3

pre- clinical trials

Answer 3

lab testing on animals or cell cultures.
assess safety and determine effectiveness

Question 4

phase 1- clinical trial

Answer 4

small group of healthy volunteers
identify side effects
trial diff doses to find safe and effective dosage

Question 5

phase 2 - clinical trial

Answer 5

small group of patients (100-300) test if drug works

Question 6

phase 3 - clinical trial

Answer 6

double blind trial
larger group (1000-3000)
randomly assigned
test group given drug control gorup given placebo
check efficacy and side ffects
improve validity

Question 7

after licencing

Answer 7

drug licenced, data no efficacy and safety continue to be monitored

Question 8

placebo

Answer 8

inactive compiund

Question 9

double blind trial

Answer 9

neither doctor or patient know if they are giving group drug or placebo.
prevents psychosomatic influence