Drug Therapy: Typical Antipsychotics Flashcards

1
Q

Also known as conventional or first-generation antipsychotics and are the oldest type of drug used to treat schizophrenia

A

These include chlorpromazine and are DA antagonists

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2
Q

These drugs bind to a group of DA receptors called D2 receptors without stimulating them

A

In doing so this drug blocks the receptor sites so the post synaptic neuron cannot be activated by DA

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3
Q

This reduces DA activity in the brain most importantly in the meso limbic pathway

A

The effect of this is s reduction in positive symptoms ed hallucinations and delusions within about 48 hours of the first dose

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4
Q

Supporting evidence for the effectiveness of typical antipsychotics
Leucht

A

Meta-analysis of 65 studies involving nearly 6000 patients who had either been given typical or atypical antipsychotics. Some given a placebo, others remained on antipsychotics
Within 12 months 64% of placebo patients had relapsed whereas 27% of those on antipsychotics

Supports the effectiveness, symptom-free for longer

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5
Q

They produce extra pyramidal side effects

A
Typical antipsychotics affect extrapyramodal area= helps control motor activity 
Drugs sometimes produce movement problems
Tardive dyskinesia (involuntary contortions of tongue and face) 30% of patients 

So distressing leads to lack of compliance and the drug is ineffective

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6
Q

They produce extra pyramidal side effects

A
Typical antipsychotics affect extrapyramodal area= helps control motor activity 
Drugs sometimes produce movement problems
Tardive dyskinesia (involuntary contortions of tongue and face) 30% of patients 

So distressing leads to lack of compliance and the drug is ineffective

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