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Medicine > Drug Toxicities > Flashcards

Drug Toxicities Flashcards

1
Q

N/V, increased liver enzymes, increased PT at 24-48 hrs

A

Acetaminophen OD
Dx blood level
Tx: charcoal if within 4 hours of ingestion
N-acetylcysteine within 8 hours

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2
Q

mucosal burn, dysphagia and drooling

A

alkali agents ex batteries

NPO

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3
Q

delirium, mydriasis, fever, urinary retention

A

Anticholinergic

Tx: Physostigmine

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4
Q

white horizontal stripes on fingernails, N/V/D, seizures and shock

A

Arsenic

Tx: Dimercaprol

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5
Q

Tinnitus, respiratory alkalosis, anion gap metabolic acidosis, nml serum osm

A

ASA

Tx: bicarb, dialysis

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6
Q

Slurred speech, ataxi, drowsiness

A

Benzodiazepines

Tx: flumazenil if iatrogenic OD

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7
Q

Bradycardia, heart block, obtundation, hyperkalemia

A

B-Blocker

Glucagon and IV calcium

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8
Q

Headache, N/V, confusion, coma, cherry-red skin

A

CO
dx: carboxy-hemoglobin
Tx: 100% O2 or hyperbaric oxygen

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9
Q

almond-scented breath, coma

A

Cyanide

Antidote: sodium nitrate, sodium thiosulfate, hydroxocobalamine

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10
Q

yellow halos, bradycardia, heart block, hyperkalemia

A

Digoxin

Dx: antidigoxin, Fab fragments

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11
Q

Calcium oxalate crystals in urine, anion gap, metabolic acidosis with high sOsm

A

Ethylene glycol
Dx: Osm gap
Tx: Fomepizole

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12
Q

Bleeding and thrombocytopenia

A

Heparin
Dx: increased PTT
Tx: protamine

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13
Q

Vomiting, bloody diarrhea, acidosis, CXR showing radiopaque tablets

A

Iron

Tx: Deferoxamine

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14
Q

Confusion, peripheral neuropathy (seizure)

A

Isoniazid

Tx: Pyridoxine

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15
Q

Microcytic anemia with basophilic stippling, ataxia, retardation, peripheral neuropathy

A

Lead

Tx: EDTA, Dimercaprol

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16
Q

Erethism, decreased memory, insomina, timidity, delirium

A

Mercury

Dimercaprol

17
Q

AGMA with high sOsm, blindness, optic disk hyperemia

A

Methanol

Tx: Bicarb, Fomepizole

18
Q

CNS/respiratory depression, miosis

A

Opiates

Tx: Naloxone

19
Q

Incontinence, cough, bronchospasm, miosis, bradycardia, heart block, tremor

A

Organophosphates

Tx: atropine, pralidoxime

20
Q

CNS depression, hypothermia, miosis, hypotension

A

Tx: supportive

21
Q

Torsades, tinnitus, vertigo widens QRS complex and prolongs QT interval

A

Quinidine

Tx: IV magnesium

22
Q

First sx: hematemesis then CNS (seizures or coma) then cardiac (arrhythmias, hypotension)

A

Theophylline

Tx: Charcoal, cardiac monitor

23
Q

Anticholinergic sx, QRS >100, tachy, coma

A

Tricyclics

Tx: Bicarb bolus

24
Q

Bleeding

A

Warfarin
elevated PT
Tx: Vit K

25
Q

vertical nystagmus

A

PCP

26
Q

Fluphenazine tox

A

hyperthermia

Medicine (8 decks)

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