Drug used in Osteoporosis & Osteomalacia

Question 1

___________ (osteoporosis/paget disease) is usually limited to one or a few bones

Answer 1

Paget disease

Question 2

Bone undergoes remodeling, with about ___ of the skeleton replaced each year.

Answer 2

10%

Question 3

What are the strategies to reduce bone loss in postmenopausal women?

Answer 3

Adequate intake of calcium and vitamin D
Weight-bearing exercise
Smoking cessation
Avoidance of excessive alcohol intake

Question 4

Name two calcium supplements

Answer 4

calcium carbonate

calcium citrate

Question 5

Calcium carbonate has ____ elemental calcium.

Answer 5

40%

Question 6

How should we take calcium carbonate for the best absorption?

Answer 6

Should be taken with meals

Question 7

Calcium citrate has ____ elemental calcium and it may be taken w/ or w/o food

Answer 7

21%

Question 8

What are the adverse effects of calcium supplementation?

Answer 8

gas and bloating

Question 9

Calcium may interfere with the absorption of some drugs. Name them

Answer 9

Iron preparations
Thyroid replacement
Fluoroquinolone
Tetracyclines

Question 10

Name the drugs that cause bone loss

Answer 10

Glucocorticoids
Heparin
Proton pump inhibitors
Furosemide
Anticonvulsants
Aluminum antacids
Aromatase inhibitors
Medroxyprogesterone acetate
Selective serotonin reuptake inhibitors
Thiazolidinediones
Thyroid (excessive replacement)

Question 11

Use of prednisone 5mg/d for ____ months or more is a significant risk factor for osteoporosis.

Answer 11

3 months