Drugs

Question 1

Epinephrine affinity

Answer 1

B1 and B2 then alpha at higher doses

Question 2

Epinephrine indications

Answer 2

anaphylactic shock

complete heart block

cardiac arrest

Prolonged Anestetic actions

Question 3

Adverse affects of Epinephrine

Answer 3

HTN, cerebral hemmorage and arrhythmias

Question 4

Low dose effect (graph of epi)

Answer 4

up: pulse (B1)

Down: peripheral resistance (B2)

Increase in sys (B1)

Decrease in diastolic (B2)

Question 5

Epinephrine Reversal

Answer 5

Higher dose epi= pressor

Given w/ alpha antagonist =decrease in pressure. Due to unopposed beta activity.

Question 6

NE affinity

Answer 6

Alpha 1 and alpha 2 > B1

Question 7

NE lacks affinity for

Answer 7

B2

Question 8

NE acts how

Answer 8

Potent vasoconstrictor.

Increases CO.

HR may decrease slightly due to baroreceptor reflex.

Question 9

NE indications

Answer 9

Hypotension , shock

Question 10

AEs of NE

Answer 10

High risk of HTN

Question 11

NE trace

Answer 11

Lowers heart rate: (baroreceptors)
Up: Peripheral resistance (unopposed alpha 1 effect)

Overall increase in MAP

Question 12

Dopamine affinity

Answer 12

Low (D1): vasodilation in renal , mesenteric, and coronary beds.

Moderate (B1):

High (Alpha)

Question 13

Dopamine indications

Answer 13

shock and heart failure

Question 14

Dopamine AEs

Answer 14

Similar to NE… .HTN

Question 15

Phenylephrine affinity

Answer 15

alpha 1 –vasoconstriction

Question 16

Phenylephrine indications

Answer 16

hypotension/shock

nasal congestion

mydriasis

Question 17

Phenylephrine AEs

Answer 17

reflex Brady cardia due to vasoconstriction . Has no direct effects on heart, so use when you don’t want to induce tacky

Question 18

Clonidine affinity

Answer 18

Alpha 2 agonist in CNS . Decreases SNS outflow from CNS and decreases NE release.

Question 19

Clonidine indications

Answer 19

HTN, addiction , post menopausal hot flashes

Question 20

Brimonidine affinity

Answer 20

Alpha 2 agonist -topical use to treat glaucoma.

Question 21

Dobutamine affinity

Answer 21

B1 (B2>alpha)- increases contractile strength . . more than in increases rate

Indications: cariogenic shock and heart failure

Question 22

Isoproterenol affinity

Answer 22

Nonselective beta agonist

Question 23

Isoproterenol indications

Answer 23

infrequently used for complete heart block. Cardiac arrest.

Question 24

Isoproterenol AEs

Answer 24

Arrythmia

Question 25

Albuterol, Metaproterenol, terbutaline

Answer 25

B2 agonist

Question 26

Albuterol, Metaproterenol, terbutaline indications

Answer 26

bronchodilation asthma , COPD,, can also be used to relax the uterus to inhibit premature labor.

Question 27

Isoproternol trace

Answer 27

Pulse: increase (B1 + baro-reflex) PR: decrease (B2) MAP: inchanged(diastolic decrease and systolic increase)

Question 28

Initital vasopressor of choice with septic shock, cardogenic shock, and hypovolemic shock

Answer 28

NE

Question 29

Initial vasopressor when tachyarrythmias preclude use of NE

Answer 29

Phenylephrine

Question 30

Alternative to NE in septic shock in highly selected patients (compromised systolic function or bradycardia and a low risk of tachyarrthmias).

Answer 30

Dopamine

Question 31

Initial agent of choice with low CO and maintained blood pressure.

Answer 31

Dobutamine

Question 32

Mirabegron mechanism

Answer 32

relaxes bladder detrusor muscle .

Question 33

Ephedrine mechanism

Answer 33

alpha , B1 and B2 affinity . . . Increases NE release . CNS stimulant

Question 34

AMphetamine

Answer 34

increase NE and DA from storage vesicles.

Question 35

Cocoaine

Answer 35

blocks NE and Epi reuptake also blocks DAT and SERT

Question 36

MDMA

Answer 36

increases serotonin release. Blocks NET, DAT, SERT release.

Question 37

Phenoxybenzamine vs Phentolamine

Answer 37

Phenoxy: long acting . Irreversible. Can cause hypotension or relfextachy . Phentolamine : short acting . Competitive. Can cause hypotension or reflex tacky

Question 38

Alpha 1 blocker for HTN

Answer 38

prazosin

Question 39

A 1 blocker for HTN and BPH

Answer 39

Terazosin

Question 40

A 1 blocker for BPH only

Answer 40

Tamsulosin