Drugs

Question 1

Cyclosporine

Answer 1

Blocks T cell sig 1 ( inhibits calcineurin)
Used: Organ transplant and RA
AE: infections and malignancies (all immuno drugs), Nephro and HT

Question 2

Betatacept

Answer 2

MOA: CTLA-4 bindings to B7
used: Organ transplant
AE: infection and malignancies (PTLD)

Question 3

Natalizumab

Answer 3

MOA: inhibit T cell Extravasation (X VTLA-4 into INFLAMED TISSUE)
Used: MS
AE: infections and malignancies, PML

Question 4

Rituximab

Answer 4

MOA: CD20 in B cells to cause death by NK (ADCC or Complement)
Used: RA, SLE, MS, non-hodge lymphoma
AE: hep b reaction and PML

Question 5

Prednisone

Answer 5

MOA: bind to GCR
Used: organ, chronic inflam, RA, MS
AE: Cushing disease (weight gain, weak skin, moonface, weak bone, fluid retention

Question 6

Infliximab

Answer 6

MOA: mAb prevents TNF from activating receptors

Question 7

Hyperacute rejection

Answer 7

When: Minutes to days
how: preexisting ab
Dmg: Vessel thrombosis

Question 8

Acute Rejection

Answer 8

10-13 days
CD4 and CD8 T cells
Th-stim dmg and CTL

Question 9

Accelerated rejetion

Answer 9

6-8 days
how: effector M t cells
same as accute but stronger

Question 10

Chronic Rejection

Answer 10

Months to years
all cells
Cytotoxic and fibrosis

Question 11

Vaccine - live attenuated

Answer 11

IgG, has CD8 T cell immunity, very effective, safe but lowest, no Adjuvant

Question 12

Vaccine - Inactive

Answer 12

IgG no CD8 T cell immunity, good effe, no Adjuvant

Question 13

Vaccine - Subunit recombo or purified, toxoid, congjuate

Answer 13

IgG, no t cell, needs adjuvant