Drugs Flashcards
Not an exhaustive deck. Just some of the drugs. Cards describe mechanism of action and conditions treated
AZT (Zidovudine) and ddl
Inhibit DNA synth by reverse transcriptase. HIV tx.
Cisplatin
Alkylating agent (ish) even though it has a Pt group. Binds to DNA bases and causes cross-linking = apoptosis. Tx in cancer
Actinomycin D
Intercalating agent –> block transcription of DNA. Tx in cancers.
Puromycin
Stops translation. Part of molecule resembles the 3’ end of the aminoacylated tRNA. Enters the A site and transfers to the growing chain –> premature chain release.
Rifampicin
Antibiotic. Blocks RNA Pol exit channel.
Acyclovir
Anti-viral (Herpes). Stops DNA replicaiton. Resembles a nucleotide but doesn’t have a 3’ OH. Can be added to the chain but nothing can be added to it.
Asprin
Essentially, prevents phosphorylation of IKB so that NF-(Kapa)B is still bound (to IKB) and can’t get into the nucleus –l expression of inflammation response protein.
Interferon
Phosphorylates eIF2-alpha –| cap-dependent translation in response to viral infection (secreted by a virally infected to cell to other non-infected cells.)
Gleevec (imatinib)
Binds close to the ATP binding site of bcr-abl (a tyrosine kinase) preventing transfer of phosphate. Tx in CML (chronic myelogenous leukemia).
Velcade (bortezomib)
Multiple myloma tx. Basically –> proteasome inhibitor –> may prevent degradation of pro-apoptotic factors that are ubiquitylated.
Remicade
Monoclonal antibody. Tx RA and other stuff.
Rituxan
B Cell monoclonal antibody. Tx of lymphoma, leukemia and anti-rejection drug.
Doxorubicin
Intercalating agent –> block transcription of DNA. Tx in cancers.
