Drugs

Question 1

ezetimibe

Answer 1

intestinal cholesterol absorption inhibitor. upregulates LDL-R

Question 2

fibrates

Answer 2

activate LPL and lower TG

Question 3

beta-sitosterol

Answer 3

compete with cholesterol in micelle formation. poorly absorbed.

Question 4

campesterol

Answer 4

compete with cholesterol in micelle formation. poorly absorbed.

Question 5

stigmasterol

Answer 5

compete with cholesterol in micelle formation. poorly absorbed.

Question 6

sitostanol

Answer 6

compete with cholesterol in micelle formation. poorly absorbed.

Question 7

compestanol

Answer 7

compete with cholesterol in micelle formation. poorly absorbed.

Question 8

stigmastanol

Answer 8

compete with cholesterol in micelle formation. poorly absorbed.

Question 9

cimetidine

Answer 9

h2-receptor blocker to inhibit acid secretion

Question 10

misoprostol

Answer 10

prostaglandin E1 analogue; used for protection in peptic ulcers

Question 11

sucralfate

Answer 11

forms an ulcer-adherent complex with proteins; ulcer protection and treatment

Question 12

pectin

Answer 12

anti-diarrhea (adsorbent)

Question 13

guar gum

Answer 13

anti-diarrhea (adsorbent)

Question 14

bismuth (think pepto bismol)

Answer 14

anti-diarrhea (adsorbent)

Question 15

codeine

Answer 15

pain killer, anti-diarrheal (antimotility)

Question 16

loperamide

Answer 16

anti-diarrhea (anti cholinergic, antimotility)

Question 17

diphenoxylate

Answer 17

anti-diarrhea (anti cholinergic, antimotility)

Question 18

aluminum

Answer 18

antacid; becomes insoluble with phosphate and causes constipation

Question 19

magnesium

Answer 19

antacid; causes diarrhea

Question 20

maalox

Answer 20

antacid; middle ground of side effects

Question 21

calcium

Answer 21

may cause renal stones and constipation

Question 22

-tidine

Answer 22

acid reflux relief; H2 receptor blockers

Question 23

-prazole

Answer 23

proton pump inhibitors; bind irreversibly

Question 24

verapamil

Answer 24

calcium channel blocker; antispasmodic in GI, side effects in CV

Question 25

diltiazem

Answer 25

calcium channel blocker; antispasmodic in GI, side effects in CV

Question 26

pinaverium bromide

Answer 26

calcium channel blocker; selective for GI

Question 27

nitroglycerin

Answer 27

relax SMCs by converting to NO

Question 28

buscopan

Answer 28

block muscarinic receptor on SMCs to block effects of Ach

Question 29

TCA (tricyclic antidepressant)

Answer 29

GI pain

Question 30

SSRI (selective serotonin reuptake inhibitor)

Answer 30

GI pain

Question 31

amitriptyline

Answer 31

TCA; GI pain med

Question 32

nortriptyline

Answer 32

TCA; GI pain med

Question 33

desipramine

Answer 33

TCA; GI pain med

Question 34

imipramine

Answer 34

TCA; GI pain med

Question 35

citalopram

Answer 35

SSRI: GI pain med

Question 36

fluoxetine

Answer 36

SSRI: GI pain med

Question 37

paroxetine

Answer 37

SSRI: GI pain med

Question 38

sertraline

Answer 38

SSRI: GI pain med

Question 39

metoclopramide

Answer 39

prokinetic (proximal gut) and anti-emetic; weak 5HT4 agonist and 5HT3 antagonist

Question 40

domperidone

Answer 40

prokinetic (proximal gut) and anti-emetic

Question 41

erythromycin

Answer 41

prokinetic; acts on motilin receptors on SMCs and Ach neurons

Question 42

prucalopride

Answer 42

prokinetic in distal bowel

Question 43

psyllium (seed husks)

Answer 43

constipation relief

Question 44

bran

Answer 44

constipation relief

Question 45

docusate sodium

Answer 45

stool softener

Question 46

bisacodyl

Answer 46

laxative

Question 47

sennoside

Answer 47

laxative

Question 48

gravol (dimenhydrinate)

Answer 48

antiemetic; anti-nausea associated with balance

Question 49

phenothiazine

Answer 49

anti-nausea associated with chemicals

Question 50

ondansetron

Answer 50

anti-nausea associated with chemicals and anti-vagal

Question 51

disulfiram

Answer 51

helps chronic alcoholism; inhibits aldehyde dehydrogenase, so causes acute reactions to alcohol

Question 52

clopidogrel

Answer 52

anti-platelet agent requiring 2C9 activation

Question 53

aspart

Answer 53

fast-acting insulin

Question 54

lispro

Answer 54

fast-acting insulin

Question 55

glulisine

Answer 55

fast-acting insulin

Question 56

NPH insulin

Answer 56

intermediate-insulin

Question 57

detemir

Answer 57

long-acting insulin

Question 58

glargine

Answer 58

long-acting insulin

Question 59

glyburide

Answer 59

sulfonylurea

Question 60

glimepride

Answer 60

sulfonylurea

Question 61

repaglinide

Answer 61

meglitinide

Question 62

propanolol

Answer 62

beta-blocker; can potentiate hypoglycemia effects of sulfonylureas and meglitinides

Question 63

pioglitazone

Answer 63

thiazolidinedione

Question 64

rosiglitazone

Answer 64

thiazolidinedione

Question 65

exenatide

Answer 65

incretin (injected)

Question 66

januvia

Answer 66

DPP-4 inhibitor

Question 67

-gliptin

Answer 67

DPP-4 inhibitor (keeps GLP-1 functioning)

Question 68

canagliflozin

Answer 68

SGLT2 inhibitor

Question 69

acarbose

Answer 69

Glucosidase inhibitor

Question 70

-dronate

Answer 70

bisphosphonate

Question 71

denosumab

Answer 71

RANKL inhibitor

Question 72

teriparitide

Answer 72

PTH analog

Question 73

loperamide

Answer 73

anti-diarretic