Drugs

Question 1

Imatinib

Answer 1

Tyrosine kinase inhibitor

For t(9;22) in CML and B-ALL
--> creates Bcr-Abl fusion gene which makes protein w/ ty kinase ax

Question 2

All Trans Retinoic Acid

Answer 2

Matures the cells and corrects the coagulation

t(15;17) in APL subtype of AML
–> PML-RARalpha fusion gene = arrest at promyelocyte stage, medical emergency due to DIC

Question 3

Blinatumomab

Answer 3

Bispecific T cell Ab that directs cytotoxic T cells to CD19 expressing B cells

For ALL

Question 4

Cladribine

Answer 4

Adenosine deaminase inhib = adenosine accum to toxic levels in neoplastic b cells

For Hairy Cell leukemia

Question 5

Rituximab

Answer 5

Anti CD20 mAb (mouse is the variable region)
Mechs: Complement dependent cytotoxicity; Antibody Dependent Cell cytotoxicity; Apoptosis

For Follicular Lymphoma

Question 6

EPO

Answer 6

-for CKD, chemo induced anemia

SE: HTN, headache, venous thrombosis, pure red cell aplasia (rare)

Question 7

TPO receptor agonists

Answer 7

Eltrombopag (oral), Romiplostim (subQ)
tx thrombocytopenia
SE: headache, venous thrombosis, myelofibrosis

Question 8

Filgrastim

Answer 8

recombinant G-CSF
prevents inf in pts w/ chemo induced neutropenia
SE: fever, bone pain in pelvis/hip, pumonary edema (rare)

Question 9

Desmopressin

Answer 9

Synthetic analogue of vasopressin (ADH analogue)

Increases vWF release from Wiebel-Palade bodies of endothelial cells

Tx for von wilebrand disease