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PT2 Neuro 1-5 > Drugs > Flashcards

Drugs Flashcards

(47 cards)

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1
Q

phenytoin MOA

A
  • blocks high frequency voltage gated Na-channels

- antagonizes NMDA

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2
Q

carbamazepine MoA

A

-blocks high frequency voltage gated Na-channels

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3
Q

phenytoin adverse reactions

A
  • gingival hyperplasia
  • osteoporosis
  • dyskinesias
  • hepatic failure
  • cognitive impairment
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4
Q

oxcarbazepine MoA

A

-blocks high frequency voltage gated Na-channels

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5
Q

gabapentin MoA

A
  • Ca channel blocker

- suppress NMDA receptor

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6
Q

carbamazepine adverse reactions

A
  • blurry vision
  • rash
  • osteoporosis
  • sexual dysfunction
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7
Q

levetiracetam MoA

A

-modulates kainate receptor (glutamate)

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8
Q

pregabalin MoA

A
  • increase glutamic acid decarboxylase

- suppresses Ca current

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9
Q

valproate adverse reactions

A
  • weight gain
  • tremor
  • behavioral changes
  • PCOS
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10
Q

phenobarbital MoA

A

-prolong GABA channel opening

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11
Q

diazepam MoA

A

-increase frequency of GABA channel opening

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12
Q

ethosuximide adverse reactions

A
  • nausea
  • fatigue
  • headache
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13
Q

lamotrigine MoA

A
  • blocks high frequency voltage gated Na-channels
  • blocks kainate receptors
  • H-current enhancement
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14
Q

lacosamide MoA

A

-enhances slow inactivation of voltage gated Na channels

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15
Q

gabapentin adverse reactions

A
  • weight gain
  • somnolence
  • dizziness
  • fatigue
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16
Q

tiagabine MoA

A

-interferes with GABA reuptake

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17
Q

zonisamide MoA

A
  • blocks high frequency voltage gated Na-channels

- Ca channel blocker

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18
Q

lamotrigine adverse reactions

A
  • rash
  • dizziness
  • blurred vision
  • headache
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19
Q

lacosamide adverse reactions

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A

dizziness
somnolence
headache

20
Q

topiramate adverse reactions

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A
  • paresthesia
  • weight loss
  • psychomotor slowing
21
Q

tiagabine adverse reactions

Study These Flashcards
A
  • somnolence
  • nausea
  • tremor
  • weight gain
22
Q

zonisamide adverse reactions

Study These Flashcards
A
  • paresthesia
  • dizziness
  • ataxia
  • weight loss
23
Q

oxcarbazepine adverse reactions

Study These Flashcards
A
  • rash
  • dizziness
  • fatigue
  • nausea
24
Q

levetiracetam adverse reactions

Study These Flashcards
A
  • depression
  • dizziness
  • headache
  • drowsiness
25
pregabalin adverse reactions
- weight gain - blurry vision - dizziness - sleepiness
26
diazepam adverse reactions
- drowsiness - dizziness - fatigue
27
phenobarbital adverse reactions
- changes in sexual function - drowsiness - irritability - loss of coordination
28
valproate MoA
- blocks voltage gated Na channels - enhance GABA transamission - modulates Ca channels
29
ethosuximide MoA
-blocks low threshold Ca channels
30
topiramate MoA
- blocks high frequency voltage gated Na-channels - increases Cl opening frequency via GABA - antagonizes glutamate action
31
vigabatrin MoA
irreversibly inhibits GABA transaminase (GABA degradation)
32
vigabatrin adverse effects
- *irreversible concentric visual loss* - weight gain - drowsiness - headache - memory problems
33
perampanel adverse effects
- mood or behavioral changes - weight gain - dizziness
34
drugs that cause weight gain
``` valproic acid gabapentin pregabalin vigabatrin perampanel ```
35
drugs that cause weight loss
topiramate zonisamide felbamate
36
eslicarbazepine adverse effects
-rash
37
drugs that cause osteoporosis
- carbamazepine - barbituates - phenytoin - oxcarbazepine - valproate
38
drugs that alter connective tissue metabolism
phenytoin | phenobarbital
39
drugs that cause neuropathy
phenytoin | carbamazepine
40
ezogabine adverse effects
- retinal pigment changes, blue discoloration of skin, sclera and nails - may lead to vision loss
41
valproic acid teratogen effect
oral cleft, neural tube defects, hypospadias, cardiac malformations, polydactyly
42
carbamazepine teratogen effect
neural tube defects
43
phenobarbital teratogen effect
cardiac malformation
44
drugs that cause oral cleft defect
- phenytoin - phenobarbital - carbamazepine - tipiramate - valproic acid
45
felbamate MoA
- blocks voltage gated Na channels at high firing frequency | - modulates NMDA and GABA receptors
46
felbamate side effects
aplastic anemia | weight loss
47
ezogabine MoA
K channel opener

PT2 Neuro 1-5 (4 decks)

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