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Flashcards in Drugs Deck (5)
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1

What are the extra pyramidal side effects? (4)

What class of anti-psychotics are particularly associated with them?

Parkinsonism, Acute dystonias (torticollis, oculogyric crisis), Akathisia, Tardive Dyskinesia ( Procyclidine)


More commonly associated with typical/first generation antipsychotics

2

What are the 8 main domains of side effects to antipsychotics?

i) EPS - Parkinsonism, Akathisia, Acute Dystonia, Tardive Dyskinesia

ii) Thrombophilic - ELDERLY. Risk of stroke and VTE.

iii) Antimuscarinic - dry mouth, blurred vision, urinary retention, constipation

iv) Metabolic/Endocrine - weight gain, sedative, galactorrhoea, impaired glucose tolerance

v) Neuroleptic malignant Syndrome - pyrexia, muscle stiffness

vi) reduced seizure threshold (more associated with atypicals i.e. clozapine)

vii) Cardiac - Prolonged QT

viii) Haematological - agranulocytosis, neutropenia

3

Features of benzodiazepine withdrawal syndrome (9)

Perceptual disturbance
Loss of appetite
Insomnia
Irritability
Anxiety
Tremor
Tinnitus
Perspiration
Seizures

4

Most dangerous TCA in overdose?

Dosulepin and Amitiptyline

- Lofepramine is safest TCA

5

Describe the actions of antipsychotics

D2 Receptor antagonists
- Block DA transmission in mesolimbic pathways.