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Flashcards in Drugs Deck (39):
1

Bisphosphonates

MOA: inhibit osteoclast formation/recruitment and induce osteoclast apoptosis
*used to treat osteoporosis

2

Colchicine

MOA: inhibits microtubule aggregation which disrupts leukocyte chemotaxis and phagocytosis
*used to treat acute gout, but has largely been replaces by NSAIDs

3

Indomethacin

Class: NSAID, Nonselective COX Inhibitor
*particularly popular for gout and ankylosing spondylitis

4

Tylenol (acetaminophen)

Class: weak inhibitor of (known) COX enzymes
Effect: central, direct analgesic effects and antipyretic. NOT ANTI-INFLAMMATORY.

5

Intra-articular Steroids

beneficial in patients with just one or two large joints affected by arthritis/gout
good option for elderly patients with other illnesses

6

Methotrexate

Class: DMARD
MOA: inhibition of AICAR transformylase and thymidylate synthetase, secondary effects on neutrophil chemotaxis
*DMARDs are expensive, but can greatly improve prognosis and slow progression. Unlike NSAIDs which offer only symptomatic relief

7

Oxycodone

Class: opioid analgesic
derived from the opium poppy, contains morphine
*tolerance and dependence develop with use
Side Effects: sedation, respiratory depression, constipation, pruritis

8

Fentanyl

Class: opioid analgesic
Strongest opioid analgesic
derived from the opium poppy, contains morphine
*tolerance and dependence develop with use
Side Effects: sedation, respiratory depression, constipation, pruritis

9

Cyclophosphamide

Class: DMARD
MOA: cross-link DNA to prevent cell replication
*DMARDs are expensive, but can greatly improve prognosis and slow progression. Unlike NSAIDs which offer only symptomatic relief

10

Pregabalin

Class: Anticonvulsant
*used as a non-opioid analgesic
*more useful for neuropathic pain

11

Probenecid

Class: Uricosuric
MOA: increase renal clearance of uric acid by inhibiting tubular absorption.
Side Effects: GI and kidney stones
*used for gout prophylaxis

12

Ibuprofen

Class: NSAID, Nonselective COX Inhibitor
*often prescribed in lower doses with analgesic but not anti-inflammatory efficacy

13

Aspirin

Class: NSAID, Nonselective COX Inhibitor
*binds irreversibly

14

Celecoxib

Class: NSAID, COX-2 Selective
Effects: analgesic, antipyretic, and anti-inflammatory. No effect on platelet aggregation
*incidence of cardiovascular thrombotic events associated with COX-2 Inhibitors

15

Meloxicam

Class: NSAID, COX-2 Selective
Effects: analgesic, antipyretic, and anti-inflammatory. No effect on platelet aggregation
*incidence of cardiovascular thrombotic events associated with COX-2 Inhibitors

16

Cyclosporine

Class: DMARD
MOA: inhibits interleukin-1 and interleukin-2 receptor production
*DMARDs are expensive, but can greatly improve prognosis and slow progression. Unlike NSAIDs which offer only symptomatic relief

17

Azathioprine

Class: DMARD
MOA: Suppresses B cell and T cell function, immunoglobulin production, and interleukin-2 secretion
*DMARDs are expensive, but can greatly improve prognosis and slow progression. Unlike NSAIDs which offer only symptomatic relief

18

Mycophenolate Mofetil

Class: DMARD
MOA: Active product inhibits cytosine monophosphate dehydrogenase and T cell lymphocyte proliferation
*DMARDs are expensive, but can greatly improve prognosis and slow progression. Unlike NSAIDs which offer only symptomatic relief

19

Gold Compounds

Class: DMARD
MOA: Alter the morphology and functional capabilities of human macrophages
*DMARDs are expensive, but can greatly improve prognosis and slow progression. Unlike NSAIDs which offer only symptomatic relief

20

Sulfasalazine

Class: DMARD
MOA: IgA and IgM rheumatoid factor production are decreased
*DMARDs are expensive, but can greatly improve prognosis and slow progression. Unlike NSAIDs which offer only symptomatic relief

21

Etanercept

Class: Anti-TNF
MOA: cytokine receptor fusion protein

22

Infliximab

Class: Anti-TNF
MOA: anti-TNF chimeric monoclonal antibody

23

Adalimumab

Class: Anti-TNF
MOA: Anti-TNF monoclonal antibody

24

Rituximab

B-cell depleting agent monoclonal antibody

25

Abatacept

T-cell co-stimulation inhibitor (receptor-ligand)

26

Leflunomide

Cell growth arrestor (G1 phase)

27

Anakinra

Class: IL-1 inhibitor
MOA: IL-1 cytokine receptor decoy

28

Secukinumab (Cosentyx)

Class: IL-17A inhibitor
MOA: anti-IL-17A monoclonal antibody
*used for moderate to servere plaque psoriasis

29

Ixekizumab (Taltz)

Class: IL-17A inhibitor
MOA: IL-17A receptor antagonist
*used for moderate to severe plaque psoriasis

30

Corticosteroids

Short/medium duration: hydrocortisone (cortisol), cortisone, prednisone
Intermediate duration: Triamcinolone
Long Acting: Dexamethasone

31

Allopurinol

Class: Xanthine Oxidase Inhibitor
MOA: blocks conversion of xanthine to uric acid
*used for gout prophylaxis

32

Febuxostat

Class: Xanthine Oxidase Inhibitor
MOA: new class of XO inhibitors. More selective than allopurinol. Little dependence on renal excretion
*used for gout prophylaxis

33

Sulfinpyrazone

Class: Uricosuric
MOA: increase renal clearance of uric acid by inhibiting tubular absorption.
Side Effects: GI and kidney stones
*used for gout prophylaxis

34

Lesinurad (Zurampic)

Class: Uricosuric
MOA: inhibit urate transporter URAT1 (responsible for the majority of renal absorption of uric acid)
*used for gout prophylaxis

35

Opioid Analgesic Strength

Fentanyl > Hydromorphone > Oxycodone
Side Effects: sedation, respiratory depression, constipation, pruritis

36

Amitriptyline

Class: SSRI
*used as a non-opioid analgesic
*more useful for neuropathic pain

37

Duloxetine

Class: SSRI
*used as a non-opioid analgesic
*more useful for neuropathic pain

38

Gabapentin

Class: Anticonvulsant
*used as a non-opioid analgesic
*more useful for neuropathic pain

39

Carbamazepine

Class: Anticonvulsant
*used as a non-opioid analgesic
*more useful for neuropathic pain