Drugs Flashcards
(23 cards)
Fluoxetine
SSRI
Sertraline
SSRI
Paroxetine
SSRI
Fluvoxamine
SSRI
Citalopram
SSRI
Escitalopram
SSRI
Flumazenil
Benzodiazepine OD antedote
SSRI indications
Depression Anxiety OCD Bulimia PTSD
Benzodiazepines indications
Anxiolytics Anti insomnia Anti epileptic Muscle relaxant Alcohol withdrawal Anaesthetic
Diazepam
Long acting benzodiazepine
Chlordiazepoxide
Long acting benzodiazepine
Alcohol withdrawal Tx
Oxazepam
Short acting benzodiazepine, use in alcohol withdrawal if have kidney failure
Temazepam
Short acting benzodiazepine
Lorazepam
Short acting benzodiazepine
SEs of benzodiazepines
- drowsiness
- decreased concentration
- decreased problem solving ability
- decreases reaction times
Paradoxical stimulation:
- fast speech
- excitement
- restlessness
Tx of OD: flumazenil
SEs of chronic use of benzodiazepines
Tolerance, addiction, withdrawal so: insomnia, anxiety, seizures.
Tx: more benzodiazepines
SEs of SSRIs
- anxiety
- insomnia
- GI disturbance
- sexual dysfunction
- SIADH
Also:
- Suicudal idealisations (<25 years)
- Serotonin syndrome
Serotonin syndrome
Overstimulation of the nervous system.
Occurs in individuals who take combinations of other antidepressants that increase serotonin levels.
Skin flushing Hypothermia Muscle ridigidty Seizures Coma Agitation
Tx of Serotonin Syndrome
Cyproheptadine
Sertotonin antagonist, blocks 5 HT2 receptors
SE if citalopram
Prolonged QT interval.
Plus SSRI side effects
Are SSRIs safe in pregnancy
Category C - potential risk.
But paroxetine is category D and can cause congenital heart defects.
Paroxetine SEs
SSRI side effects
Pregnancy: congenital heart defects
Which SSRIs are cP450 inhibitors?
Fluoxetine, fluvoxamine and paroxetine.
Hence they can reduce the elimination rate and cause build up of benzodiazepines.
