Drugs

Question 1

Penicillin resistance comes from bacteria that contains?

Answer 1

Beta-lactamase

Question 2

MOA of amoxicillin

Answer 2

Disrupts cell wall & inhibits cross linking between peptidoglycan chain

Question 3

Why doesn’t amphotericin B work aginst bacteria?

Answer 3

Ergosterol (fungus cell wall )

Question 4

Polyene antifungal are specific to fungus because?

Answer 4

It attack the sterol that are present in fungi but not bacteria

Question 5

What binds to 30s ribosome & inhibits mRNA trnslation?

Answer 5

AMG

Question 6

What don’t you treat patients with penicillin & erythromycin?

Answer 6

Penicillin only works on growing cells

Question 7

MOA of fluorouracil?

Answer 7

Suicide inhibitor of thymidylate synthase

interefers with DNA synthesis by blocing thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid

Question 8

What is a reversible nonselective COX inhibitor that is more potent than aspiring

Answer 8

Naproxen

Question 9

What medication blocks prostaglandins?

Answer 9

Aspirin

Question 10

What’s the lab test for wafarin?

Answer 10

Prothrombin test (increases)
(Hemophilia has increased PPT)

Question 11

Sulfonamides compete with which molecule in their MOA?

Answer 11

PABA to inhibit folic acid synthese –> can’t make purines/ pyrmidines

Question 12

What does sulfonamides block on top of dihydrofolate?

Answer 12

Purines & pyrmidine synthess

Question 13

How does detergent kill bacteira by interfering with function of cell membranes?

Answer 13

Destroy fatty cell parts

Question 14

MOA of which drug is inhibition of Na/K ATPase that causes increase in intracellular Na levels?

Answer 14

Digoxin

Question 15

What medication is a DNA gyrase inhibitor?

Answer 15

Ciprofloxacin (end with oxacins)

Question 16

What’s the MOA of clindamycin?

Answer 16

50s ribosomes

Question 17

How does rifampin work?

Answer 17

RNA synthesis inhibitor

TX of TB; stops mRNA transcription

Question 18

What’s the most common bacteria vaccine given in US?

Answer 18

DTP

Question 19

Bordetella pertusis vaccine is what type of vaccine?

Answer 19

Killed

Question 20

Live attenuated vaccine is an ?

Answer 20

Active immunity

Sabin: oral/alive; SalK: killed

Question 21

What’s the antibiotic used for meningitis caused by Haemophilus influenza?

Answer 21

Ceftriaxone

Question 22

MOA of Viagra?

Answer 22

inhbit CGMP specific PDE5 which regulates blood flow into penis

Question 23

All will depress respiration excpet?

Answer 23

Cocaine