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3b > Drugs > Flashcards

Drugs Flashcards

1
Q

Aripiprazole

A

Atypical antipsychotic

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2
Q

Ranitidine

A

H2 R blocker

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3
Q

Name three first generation APs

A

Haloperidol
Flupentixol
Prochlorperazine

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4
Q

What is acute dystonic reaction.

A

Involuntary muscle spasms , can lead to airway obstruction

Most common with haloperidol

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5
Q

What side effects are most common with typical antipsychotics

A

Extrapyramidal side effects inc

  • Parkinsonian symptoms
  • tardive dyskinesia
  • dystonia and dyskinesia
  • akathesia (restlessness)
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6
Q

What is tardive dyskinesia

A

A common SE with 1st gen APs
Rhythmic involuntary facial movement involving face , tongue and jaw.
Potentially irreversible

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7
Q

Name 5 second generation APs

A 
Olanzapine
Quitiapine
Clozapine
Risoeridone
Aripiprazole
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8
Q

Why do APs cause hyperprolactineamia

A

As dopamine inhibits prolactin . APs are D2R antagonists so there is less dopamine release therefore less inhibition of prolactin

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9
Q

What are the endocrine SEs of APs

A

Hyperprolactinemia
Hyperglycaemia
Sexual dysfunction

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10
Q

What are the symptoms of hyperprolactinemia

A

Galatorrhoea
Sexual dysfunction
Reduced bone density
Breast enlargement

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11
Q

What type of drug is gentamyacin

A

Aminoglycoside

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12
Q

What is a contraindication to using gentamyacin

A

Myasthenia Gravis

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13
Q

When are peak gent levels taken

A

1hr post dose

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14
Q

What would you do if peak gent levels were too high

A

Decrease dose

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15
Q

What would you do if trough gent levels were too high

A

Decrease frequency

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16
Q

What is the first drug you give in NSTEMI, what are the treatment options after this ?

A

Asprin

1) Angiography +PCI within 120mins
2) fibrinolysis
3) medical management with clopidogrel +cardiac rehab

17
Q

Name a fibrinolytic drug

A

Alteplase

Desmoplase

18
Q

Side effects of gent

A

Ototoxicity

Nephrotoxisity

19
Q

What channel do loop diuretics act on - what action do they have

A

NKCC2

Inhibit absorption of na & cl

20
Q

What thiazide diuretic would you give in 70+s

A

Indipamide

21
Q

What is the loading dose of asprin given in NSTEMI

A

300mg

22
Q

Name three types of anti clotting drug , their indication and an example

A

Anti platelet - to prevent arterial clots - asprin /clopidogrel

Anticoagulant - heparin / warfarin -DVT

Thrombolytic - fibrinolysis - alteplase / desmoplase

23
Q

Name a rate limiting CCB

A

Verapamil

Diltiazem

24
Q

Ivabradine

A

HCN channel blocker used in angina if BB+CCB cannot be tolerated

25
Q

If a patients angina is not controlled with mono therapy atenolol (BB) what would you do

A

Add a CCB i.e. amlodipine

Not verapamil as this is rate limiting and can cause heart block when used with a BB

26
Q

What 4 drugs would you prescribe in angina pectoris

A

Asprin
Statin
GTN
BB or CCB

27
Q

What is the active ingredient in GTN

A

Isosorbide mononitrate

28
Q

What drugs are contraindicated in pregnancy

A 
Statins
Aspirin 
Warfarin 
ACEi/ ARBs
Retinoids 
Trimethoprim 
Sulphonylurias
Aminoglycosides 
Quinolones 
?AEDs
Metformin-> insulin
29
Q

Give an example of a quinolone

A

Ciprofloxacin (broad spectrum)

30
Q

What is metyrapone

A

Cortisol suppression drug

31
Q

What type of drugs are “-Zumabs”

A

Monoclonal abs

32
Q

Movicol is what type of diuretic

A

Stumulant

33
Q

What type of drug is sena

A

Stimulant laxative

34
Q

What drug is loperamide

A

Anti diarrhoeal

35
Q

What type of drugs are “-zumabs”

A

Monoclonal abs

36
Q

Give some examples of osmotic laxatives

A

Lactulose

polyethylene glycol

Magnesium citrate

37
Q

What is the medical management of cushings disease

A

Metyrapone

38
Q

What is the medical management of Addison’s disease

A

HC+ flusrocortisone

3b (2 decks)

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