Drugs Acting on the GIT

Question 1

group of drugs to promote vomiting

Answer 1

emetics

Question 2

emetic of choice for dogs

Answer 2

apomorphine

Question 3

induces vomiting in cats

Answer 3

xylazine

Question 4

example of peripheral acting emetic

Answer 4

hydrogen peroxide

Question 5

group of drugs used to control vomiting

Answer 5

antiemetics

Question 6

drugs that control the chemoreceptor trigger zone and CNS control of emesis used as antiemetics for apomorphine and xylazine

Answer 6

CHLORPROzine, PROCHLORPERAzine, PROMETHAzine

Question 7

antihistamine, used for preventing motion sickness induced vomiting in cats and dogs

Answer 7

Diphenhydramine, Dimenhydrinate, Meclizine

Question 8

5-HT3 receptor antagonists, tx for severe nausea caused by chemotherapy, chemoreceptor trigger zone (CRTZ) and vagal nerve stimulation center

Answer 8

DOLAsetron, GRANIsetron, ONDANsetron

Question 9

neurokinin (NK1) receptor antagonist, stops vomiting centers

Answer 9

Maropitant

Question 10

GI prokinetic agent, stimulates upper GI motility to reduce vomiting

Answer 10

Metoclopramide

Question 11

histamine is secreted by

Answer 11

Enterochromaffin like cells

Question 12

chief cells secrete

Answer 12

pepsinogen, gastric lipase, leptin

Question 13

D cells secrete

Answer 13

somatostatin

Question 14

produce ghrelin, obestatin, serotonin abd atrial natriutic peptide

Answer 14

enterochromaffin cells

Question 15

produce mucus and bicarbonate

Answer 15

mucous cells

Question 16

secrete gastrin

Answer 16

G cells

Question 17

ions secreted at the basal side of the parietal cells in exchange to chloride

Answer 17

Bicarbonate ions

Question 18

used as treatment for GI ulcers/erosion

Answer 18

Omeprazole

Question 19

proton-pump inhibitor with similar effect to famitidine (?) and/or omeprazole, but omeprazole is considered to be more effective

Answer 19

Pantoprazole

Question 20

secretion of histamine are reduced by

Answer 20

somatostatin and prostaglandins

Question 21

primary trigger for histamine release from the enterochromaffin-like cells

Answer 21

gastrin

Question 22

inhibits histamine release

Answer 22

somatostatin, calcitonin-gene related peptide (CGRP), peptide YY, prostaglandins, galanin

Question 23

secretion of histamine is increased by

Answer 23

gastrin, aspirin, indomethacin

Question 24

prototype H2 blocker

Answer 24

Cimetidine

Question 25

a gastromucosal protectant, locally-acting treatment for GI ulcers, treatment of oral, esophageal, gastric, and duodenal ulcers

Answer 25

sucralfate

Question 26

a prostaglandin e analog, used for treating/preventing gastric ulcers

Answer 26

misoprostol

Question 27

appetite stimulant for cats

Answer 27

cyproheptadine

Question 28

appetite stimulant for dogs

Answer 28

diazepam

Question 29

used as appetite stimulant and antiemetic in dogs and cats

Answer 29

mitrazapine

Question 30

appetite stimulant for cats, treat behavioral prob in cats and dogs

Answer 30

oxazepam

Question 31

drugs that increase motility of the GI smooth muscle without acting as a purgative

Answer 31

GI stimulant

Question 32

oral GI prokinetic agent, used in several species for GI stasis, reflux esophagitis, constipation/megacolon

Answer 32

Cisapride and domperidone

Question 33

suggested for use in intestinal atony or distention

Answer 33

dexpanthenol

Question 34

indicated for rumen atony, initiate persitalsiss, emptying the bladder and stimulating skeletal muscle contractions

Answer 34

neostigmine

Question 35

pancreatic enzyme used to treat exocrine pancreatic enzyme deficiency

Answer 35

pancrealipase

Question 36

group of drugs used to increase bowel movement by loosening the stool

Answer 36

laxatives

Question 37

disccharide laxative and reducer of ammonia blood levels

Answer 37

lactulose

Question 38

surfactant , stool softener

Answer 38

docusate

Question 39

an osmotic laxative

Answer 39

glycerin (suppository)

Question 40

lubricant llaxative, usually used for horses

Answer 40

mineral oil

Question 41

laxative of choice for sand colic in horses

Answer 41

psyllium

Question 42

class of drug used to treat acute and chronic diarrhea

Answer 42

antidiarrheals

Question 43

a central a2 agonist, used as an adjunctive treatment in patients with inflammatory bowel disease

Answer 43

clonidine

Question 44

opiate agonist, anticholinergic. combined for antidiarrheal prod in dogs

Answer 44

Diphenoxylate and Atropine

Question 45

GI adsorbent/protectant

Answer 45

Kaolin/Pectin

Question 46

synthetic opiate GI motility modifier

Answer 46

loperamide

Question 47

opiate GI modifier, used as motility modifier for animals w/ diarrhea, not used in cats

Answer 47

Paregoric

Question 48

used as treatment for abdominal visceral spasm, pylorospasm or hypertrophic gastritis and associated nausea, vomiting and/or diarrhea for use in dogs and cats

Answer 48

aminopentamide and hyoscyamine

Question 49

injectable anticholinergic used in treating colic

Answer 49

N-butylscopolammonium Br

Question 50

quaternary antimuscarinic agent used for its antispasmodic/antisecretory for treatment of diarrhea, hyper reflaxic detrusor or urge incontinence and anticholinergic responsive bradycardias

Answer 50

propantheline