Drugs and the cardiovascular system Flashcards
(21 cards)
What are the 2 ACE inhibitors?
Ramipril
Lisinopril
What are the 2 key side effects of ACE inhibitors?
Dry cough
Hypotension
What are the 2 Angiotensin II receptor blockers?
Losartan
Valsartan
What are the 2 beta blockers?
Bisoprolol
Atenolol
What is the key side effect of beta blockers?
Fatigue
What are the 2 statins?
Atorvastatin
Simvastatin
What is the key side effect of statins?
Muscle aches
What are the 2 calcium channel antagonists?
Nifedipine
Amlodipine
What is the key side effect of calcium channel antagonists?
Ankle swelling
What are the 2 nitrate vasodilators?
Glycerol trinitrate (GTN)
Isosorbide mononitrate (ISMN)
What are the 2 antiplatelet categories?
COX inhibitor
ADP receptor antagonist
Which medication is a COX inhibitor used to prevent thrombosis?
Aspirin
What are the 2 ADP receptor antagonists?
Clopidogrel
Prasugrel
What is the key difference in differentiating between an NSTEMI and unstable angina?
NSTEMI - caused by partial or intermittent coronary artery occlusion with serum troponin detection
Unstable angina - caused by partial or intermittent coronary artery occlusion without serum troponin detection
What are the 2 main causes of heart failure?
Ischaemic heart disease
Hypertension
How does cardiac output change in heart failure?
Reduced CO
Do calcium channel blockers act on veins?
Do nitrates?
No
Yes
In the heart, does stimulation of B receptors cause contraction or relaxation?
Contraction
In smooth muscle, does stimulation of B receptors cause contraction or relaxation?
Relaxation
COX is required for the synthesis of what?
Thromboxane A2
Which enzyme is targeted by statins?
HMG-CoA reductase
