Drugs - Cardiac Flashcards
(27 cards)
verapamil
ccb (diphenylalklamine). V site of calcium channel. antiarrhythmic.
diltiazem
ccb (benzothiazepine). D site of calcium channel. antiarrhythmic.
nifedipine
ccb (dihydroxypyridine). N site of calcium channel. more specific to vascular SM compared to cardiac Ca channels. not for antiarrhythmia.
-olol
beta blocker
sodium nitroprusside
vasodilator. liberates NO. rapid, so given in hypertensive emergencies.
nitric oxide pathways
cGMP…MLCP;
Ca-dependent K channels to hyperpolarize cell
angina agents
nitrates
beta-blockers
ccb
nitroglycerin
rapid nitrate for acute angina. 5 min half life.
isosorbide dinitrate
nitrate for chronic angina. 1 hour half life.
isosorbide 5-mononitrate
nitrate for chronic angina. 2 to 4 hour half life.
heart failure agents
diuretics beta blocker ACE inhibitor ARB vasodilator digoxin (glycoside)
enalapril
ace inhibitor for cardiac failure
metoprolol
beta blocker for cardiac failure. Beta1 selective.
digoxin
inhibits Na/K ATPase. buildup of Na prevents extrusion of Ca in the Na/Ca exchanger. buildup of Ca increases contractions
quinidine
na-channel blocker. class Ia. primary arrhythmia syndromes.
procainamide
na-channel blocker. class Ia. ventricular tachycardia. metabolite is a k-channel blocker.
disopyramide
na-channel blocker. Class Ia
lidocaine
na-channel blocker. Class Ib
mexiletene
na-channel blocker. Class Ib
propafenone
na-channel blocker. Class 1c
flecainide
na-channel blocker 1c. a fib, CPVT
amiodarone
k-channel blocker(class III). all arrhythmias.
sotalol
non selective beta blocker. also k-channel blocker. VT, a fib.
dronedarone
k-channel blocker
