Drugs for Skeletal System Flashcards
What drug is a monoclonal antibody that binds to TNF-alpha; given by IV with methotrexate; associated with upper respiratory infections; used for the treatment of RA; chimeric
Infliximab
Drug that is an inhibitor of dihydrofolate reductase; used for the treatment of RA
Methotrexate
What are the side effects of Methotrexate?
1) Immunosuppresion
2) Nausea
3) Mucosal ulcers
4) Cirrhosis
5) Pneumonitis
What side effect of methotrexate does not go away when drug is removed?
Pneumonitis
Drug that is a recombinant protein consisting of two soluble portions of TNF-alpha receptor molecule with a Fc portion of IgG; binds to TNF-alpha; injected
Etanercept
What is a problem that may occur with infliximab?
1) Inflixmab is a chimer monoclonal antibody that may cause a hypersensitivity reaction within the body
Human monoclonal antibody for anti-TNF; injected
Adalimumab
What is given as an alternative to methotrexate? What are its side effects?
1) Leflunomide
2) Elevated liver enzymes
Drug that acts by inhibiting the activation of T cells by binding to the CD 80/86; used if anti-TNF does not work
Abatacept
When is abatacept contraindicated?
1) COPD
2) Given with anti-TNF
MOA of Leflunomide
1) Inhibitor of tyrosine kinase
2) Inhibitor of pyrmidine synthesis
Monoclonal antibody for CD20 on B cells
Rituximab
Drug that is poorly absorbed and is broken down by intestinal bacteria into a salicylate and an antibiotic; risk for hypersensitivity
Sulfasalazine
What are the adverse effects of hydroxychloroquine?
1) Corneal deposits
2) Extraocular muscle weakness
3) Loss of accommodation
4) Retinopathy
Drugs that work by inhibiting the maturation and function of mononuclear phagocytes and T cells
Gold Salts
What gold salts are water soluble and can be given IM injection; generally are given as weekly injections until 1 gm has been administered
1) Gold Sodium thiomalate
2) Aurothioglucose
What gold salt is hydrophobic and is given orally for 6-9 months; less efficacy
Auranofin
What is the most common side effect of gold salts?
Lesions of the skin and mucosal membranes
Drug that is an analog to cysteine that slows the bone destruction of RA
D-penicillamine
What are the side effects of D-penicillamine?
1) Dermatological problems
2) Nephritis
3) Aplastic anemia
Recombinant form of IL-1ra that is used to inhibit the effects of IL-1 (inhibition of collagen synthesis and increased joint degradation)
Anakinra
Antibody selective for the IL-6 receptor
Tocilizumab
What are the side effects of Tocilizumab?
1) Upper respiratory infections
2) Headache
3) Elevated BP
4) Increased LDL
5) Increases risk for cancer
Drug that causes the local depletion of substance P
Capsaicin