Drugs for Spasticity Flashcards
1
Q
Describe Spasticity:
A
intermittent or sustained involuntary contraction of skeletal muscle, causing stiffness that interferes with mobility and speech
2
Q
What is the tone if resistance is weak?
A
flaccid tone
3
Q
What is the tone if resistance is high?
A
spastic tone
4
Q
MOA: Diazepam
A
potentiate the action of GABA in the CNS
5
Q
What is the indication of Diazepam?
A
may be used in patients with muscle spasms of almost any origin
6
Q
Adverse Effects: Diazepam
A
sedation
7
Q
MOA: Baclofen
A
GABA(B) receptor agonist, inhibitory G protein= decreased Ca influx and neurotransmitter release
8
Q
Adverse Effects: Baclofen
A
-sedation (less than diazepam)
-high doses= drowsiness, respiratory depression, and coma
must be stopped slowly to avoid withdrawal
9
Q
A
