Drugs for Vasculitities and Goodpasture's Flashcards Preview

CPR II Exam 3 > Drugs for Vasculitities and Goodpasture's > Flashcards

Flashcards in Drugs for Vasculitities and Goodpasture's Deck (15)
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1
Q

The alkylating drug, cyclophosphamide is used for treatment of what?

A

malignant diseases

minimal change nephrotic syndrome (peds)

ANCA vasculities and Goodpasture’s

2
Q

What are the contraindications for Cyclophosphamide?

A

HSN reaction to the drug itself

urinary outflow obstruction

3
Q

What are the warnings of Cyclophosphamide?

A

immunosuppression

renal toxicity

cardiotoxicity

pulmonary toxicity

Veno-occlusive liver disease

embryo/fetal toxicity

4
Q

What are common side effects of cyclophosphamide?

A

neutropenia (febrile)

alopecia

fever

vomiting/diarrhea

5
Q

What are the indications for CD20 ab, Rituximab?

A

NHL

CLL

RA

ANCA vasculities and Goodpasture’s

6
Q

What are the contrainidications for Rituximab?

What is the black box warning?

A

None!

Fatal infusion reaction

TLS

severe mucocutaneous reactions

PML

7
Q

In cancer patient’s treated with Rituximab, what were the common side effects?

A

infusion reactions

fever

lymphopenia

neutropenia

8
Q

In RA patients treated with rituximab, what were the common side effects?

A

URI

nasopharyngitis

UTI

bronchitis

9
Q

What is the main toxicity when Rituximab is combined with Cisplatin?

A

Renal toxicity

10
Q

What are the indications for Azathioprine?

A

adjunct to prevent rejection in renal transplant

manage RA along with ASA/NSAIDs, or glucocorticoids

ANCA vasculities and goodpasture’s

11
Q

What are the contraindications for Azathioprine?

A

HSN to the drug

pregnancy (may increase risk for malignancy)

12
Q

What are the warnings associated with Azathioprine?

A

lymphoma and skin cancers (avoid sunlight)

*immunosupressive drug therapy should be maintained at the lowest effective levels

13
Q

What is a limitation in use for Cyclophosphamide?

A

the safety and efficacy for the treatment of nephrotic syndrome in adults or other renal disease has NOT been established

14
Q

What are the two types of ANCA assays in wide use?

A
  • indirect immunofluorescence assay using alcohol buffy coat leukocytes
  • ELISA using purified specific antigens
15
Q

What are some drugs that may induced vasculities?

A

hydralazine

propylthiouracil

methimazole

carbimazole

minocycline