Drugs Master List

Question 1

Colchicine

Answer 1

Anticancer drug that depolarizes microtubules

Question 2

Vinblastin

Answer 2

Anticancer drug that depolarizes microtubules

Question 3

Taxol

Answer 3

Anti-cancer drug that interacts with microtubules stabilizing them excessively and can lead to peripheral neuropathy

Question 4

Pancuronium

Answer 4

Competitive acetylcholine antagonist used as neuromuscular blockade during surgery

Question 5

Succinylcholine

Answer 5

Paralysis by activating nicotinic receptor holding the channel open for a long time causing inactivation causing flaccid paralysis

Question 6

Organophosphorous gases

Answer 6

Irreversibly breaks down acetylcholinesterase, leading to inactivation of sodium channels and paralysis. Example: sarin.

Question 7

Botulinum toxin

Answer 7

Destroys SNAREs proteins at the NMJ leading to reduced NT release and paralysis

Question 8

Tetanus toxin

Answer 8

Similar mechanism as botulin except does so at inhibitory interneurons leading to movement

Question 9

Physostigmine

Answer 9

Used to treat impaired NMJ function - transient Achesterase inhibitors

Question 10

Neostigmine

Answer 10

Used to treat impaired NMJ function - transient Achesterase inhibitors

Question 11

Pyridostigmine

Answer 11

Used to treat impaired NMJ function - transient Achesterase inhibitors

Question 12

Pilocarpine

Answer 12

Muscarinic agonist used in treatment of glaucoma dry mouth (xerostomia). Parasympathetic agonist. Causes ciliary muscle to contract constricting the pupil.

Question 13

Atropine

Answer 13

Ach muscarinic antagonist

Question 14

Scopolamine

Answer 14

Ach muscarinic antagonist used to prevent motion sickness

Question 15

Anti-Ach toxidrome

Answer 15

Blind as a bat (pupils dilate) mad as a hatter (delusions) red as a beet (hot dry skin) hot as a hare dry as a bone the bowel andbladder lose their tone and the heart runs alone (tachycardia

Question 16

Overdose Ach Toxidrome

Answer 16

SLUDGE - Salivation Lachrymation Urination Diarrhea GI distress Emesis

Question 17

Memantine

Answer 17

NMDA receptor blocker used in PD

Question 18

Ketamine

Answer 18

NMDA receptor blocker

Question 19

PCP

Answer 19

NMDA receptor blocker

Question 20

Benzodiazepines

Answer 20

Enhance GABAa function by increasing frequency of channel openings

Question 21

Barbiturates

Answer 21

Increase GABAa affinity for GABA and enhance channel conductance

Question 22

Propofol

Answer 22

Enhance GABA affinity and frequency of GABAa channel openings

Question 23

Neurosteroids (pregnanalone)

Answer 23

Increase GABAa receptor activity

Question 24

Gentamycin

Answer 24

Ototoxic can be paritcular problem when given as baby

Question 25

Cisplatin

Answer 25

Ototoxic drug

Question 26

Streptomycin

Answer 26

Can disrupt 8th nerve function (possibly just vestibular not auditory?)

Question 27

Tetrodotoxin

Answer 27

Sodium channel blocker injected in eye experiments

Question 28

Meclizine/Antivert

Answer 28

Antihistamine used as an antivertigo/antiemetic agent somewhat anticholinergic

Question 29

L-dopa

Answer 29

Side effects include peripheral breakdown leading to nausea and orthostatic hypotension; also hallucinations disrupted sleep

Question 30

Carbidopa

Answer 30

Peripheral inhibitor of dopa-decarboxylase can't cross the BBB prevents nausea by preventing peripheral breakdown of L-dopa

Question 31

Benserazide

Answer 31

Peripheral inhibitor of dopa-decarboxylase can't cross the BBB prevents nausea by preventing peripheral breakdown of L-dopa

Question 32

Tensilon

Answer 32

Inhibits acetylcholinesterase used in the tensilon test for myesthenia gravis