Drugs of Abuse

Question 1

Schedule I

Answer 1

LSD
Heroin
marijuana

Question 2

Schedule II

Answer 2

Opiates
Amphetamine
Cocaine
Barbituates

Question 3

Schedule III

Answer 3

Codeine+acetaminophen

Anabolic steroids

Question 4

Schedule IV

Answer 4

Benzos

Tramadol

Question 5

Schedule V

Answer 5

OTC cough meds w/ codeine

Question 6

Addiction pathway

Answer 6

Mesocorticolimbic pathway, DA

Question 7

Types of tolerance

Answer 7

• Cellular (receptor regulation)

* Metabolic (elimination)

Question 8

Physiological dependence = susbstance use disorder?

Answer 8

NO

Question 9

Alcohol

Mech

Answer 9

Up Gaba, down glutamate

Question 10

Alcohol withdrawal syndrome

Tx

Answer 10

Mild: clonidine/propranolol

Severe: Diazepam

Question 11

Alcohol relapse

Tx

Answer 11

Aversion = Disulfiram

Anti-craving =

• Naltrexone
• acamprosate
• topiramate
• SSRI

Question 12

Barbituate withdrawal
(seizures)

tx

Answer 12

Phenobarbitol

Question 13

Benzo high-dose withdrawal (seizure)

Tx

Answer 13

• Phenobarbitol

* long-acting benzo

Question 14

Methadone pharm advantages over Heroin

Answer 14

• no sharp peaks and valleys

* Methadone withdrawal less

Question 15

Opioid use disorder

Tx

Answer 15

• Methadone
• LAAM (levo-alpha-acetyl methadyl)
• Buprenorphine
• Naltrexone
• Clonidine

Question 16

Nicotine

Tx

Answer 16

• Nicotine Replacement Therapy
  (pharmacokinetics slower than smoking)
  *Bupropion (zyban) = reduce craving, decrease withdrawal
  *Varenicline (chantix) = a4b2 partial ag (less reward, less addict/craving/withdrawal) (black box PSYC)

Question 17

Cannabinoid receptor BLOCKER

Answer 17

Rimonabant

withdrawn in europe for PSYC toxic

Question 18

Endogenous cannabinoids

Answer 18

• anandamide

* 2-arachidonoyl glycerol

Question 19

Synthetic THC

Answer 19

Dronabinol (marinol Sched 3) = nausea/anorexia in AIDS/chemo

Question 20

Amphetamine

Mech

Answer 20

DA + NE release

Question 21

Cocaine

Mech + S.E.

Answer 21

DA re-uptake blocker

S.E. = premature labor, developmental abnormalities

Question 22

Stimulant OD

Answer 22

Seizures
Stroke (vasoconstricton)
psychosis

Question 23

Stimulant

Reverse tolerance

Answer 23

=senstization

UP stroke/arrythmia risk

Question 24

Stimulant withdrawal

Answer 24

depression

usually no treatment

Question 25

Stimulant Use disorder tx

Answer 25

related to route (smoking worse) VERY difficult to treat

Question 26

Stimulant Preventing relapse

Answer 26

Psychotherapy (AA) Topiramate Anti-depressants

Question 27

Hallucinogens Psychedelics : Serotonin-related

Answer 27

LSD Psilocybin DMT *Ags = 5HT/DA/Adrenergic

Question 28

Hallucinogens Psychedellics : DA/Amphetamine-related

Answer 28

MDA MDMA Mescaline *Ags= 5HT/DA/Adrergic/ 5HT reuptake inhibit

Question 29

Hallucinogens Psychedelics: Kappa opioid receptor

Answer 29

Salvinorin A

Question 30

Dissociatives

Answer 30

PCP | Ketamine

Question 31

Deliriants

Answer 31

Scopolamine | Atropine

Question 32

Hallucinagens Addiction- Tx

Answer 32

not addictive | *behavioral/social support

Question 33

Dissociatives (PCP/Ket) mech

Answer 33

general anesthetic *inhibit NMDA receptors

Question 34

PCP/ketamine CNS effects

Answer 34

* Analgesia/anesthesia * Feelings of detachment from self/environment * Hallucinations * Delusions HIGH DOSE: seizure, coma, death

Question 35

PCP/ketamine Peripheral effects

Answer 35

* Sympathomimetic : UP HR/BP/sweating | * Parasympathomimetic: UP salivation

Question 36

PCP/ketamine Tx

Answer 36

none, counseling addiction possible