Drugs Only 2

Question 1

a drug that is a precursor to dopamine and quickly taken up; increases DA levels

Answer 1

L-DOPA

Question 2

a drug that blocks TH, preventing synthesis of DA and NE

Answer 2

alpha-methyl-para-tyrosine (AMPT)

Question 3

Drug that blocks VMAT, preventing DA and NE from being packaged, and making transmitter levels drop

Answer 3

Reserpine

Question 4

a MAO inhibitor used to treat clinical depression

Answer 4

phenelzine

Question 5

A COMT inhibitor that enhances the effectiveness of L-DOPA in treating Parkinson’s disease

Answer 5

tolcapone

Question 6

drug that inhibits reuptake of all monoamines (DA, NE, 5-HT)

Answer 6

Cocaine

Question 7

drugs that inhibit reuptake of both NE and 5-HT

Answer 7

tricyclic antidepressants

Question 8

Drug that selectively inhibits reuptake of catecholamines

Answer 8

methylphenidate (ritalin)

Question 9

a drug that selectively inhbits reuptake of NE transporters

Answer 9

strattera

Question 10

drugs that reverse the DA/NE transporter so that molecules from inside the terminal are pushed out into the synapse

Answer 10

amphetamine

Question 11

an agonist that sitmulate both D1 and D2 receptors causing behavioural activation similar to that seen with cocaine and amphetamine

Answer 11

apomorphine

Question 12

an antagonist that blocks both D1-D2 receptors, reducing motivation and at higher doses, producing catalepsy

Answer 12

flupenthixol

Question 13

an antagonist that has >1000x affinity for D2 like vs D1 receptors, but binds with D2, D3 and D4 with similar affinity

Answer 13

haloperidol

Question 14

an alpha-1 receptor agonist

Answer 14

phenylephrine

Question 15

an alpha-1 receptor antagonist

Answer 15

prazosin

Question 16

alpha-2 receptor agonist that reduces NE release in both the brain and body, slowing heart rate

Answer 16

clonidine, guanfacine

Question 17

an alpha-2 receptor antagonist that blocks both postsynaptic and autoreceptors, leading to an anxiogenic type response

Answer 17

yohimbine

Question 18

an agonist for beta-1 or beta-2 receptors

Answer 18

isoproterenol

Question 19

an antagonist for beta-1 or beta-2 receptors

Answer 19

propanolol

Question 20

A nonselective antagonist for AMPA, Kainate and NMDA receptors

Answer 20

Kyunurenic acid

Question 21

a competitive antagonist that blocks both AMPA and kainate receptors but not NMDA

Answer 21

NBQX

Question 22

A competitive antagonist for NMDA receptors that block glutamate from binding

Answer 22

AP-5/APV

Question 23

Drugs that block the NMDA channel when its open; independently of glutamate binding

Answer 23

phencyclidine, ketamine, MK-801

Question 24

an agonist for mGluR 4,6,7, and 8 autoreceptors, which suppress glutamate release

Answer 24

L-AP4

Question 25

GABA-A competitive agonist (at GABA binding site)

Answer 25

muscimol

Question 26

GABA-A competitive antagonist

Answer 26

bicuculline

Question 27

GABA-A non competitive antagonist that binds inside the channel pore

Answer 27

picrotoxin

Question 28

a benzodiazepine that is used for sleep but reduces sleep quality because REM sleep is reduced over the sleep cycle; GABA-A allosteric modulator

Answer 28

diazepam

Question 29

barbiturate; GABA-A allosteric modulator

Answer 29

phenobarbital

Question 30

a GABA-B receptor agonist used as a muscle relaxant and experimental treatment for alcoholism

Answer 30

baclofen

Question 31

a GABA-B receptor antagonist that is a convulsant and is primarily used for research

Answer 31

saclofen

Question 32

positive allosteric modulators of AMPA receptors

Answer 32

ampakines

Question 33

a drug that blocks 5-HT synthesis by irreversibly inhibiting tryptophan hydroxylase

Answer 33

para-chloro-phenyl-alanine (PCPA)

Question 34

a drug that acts like amphetamine; reverses monoamine transporters to shoot 5-HT out into the synapse; was prescribed for appetite suppression in obese patients but caused cardiovascular side effects

Answer 34

fenfluramine

Question 35

A recreational drug that acts on SERT with higher affinity than DAT and NET; can cause enhanced sensations and may be used as a therapeutic agent for PTSD

Answer 35

3,4-methylenedioxymethamphetamine (MDMA, ecstasy, molly)

Question 36

drug that blocks SERT and thus acts as an SSRI

Answer 36

fluoxetine

Question 37

full agonist of 5-HT1A

Answer 37

8-OH-DPAT

Question 38

partial agonist of 5-HT1A

Answer 38

buspirone

Question 39

a 5-HT1A receptor antagonist

Answer 39

WAY-100635

Question 40

a 5-HT2A agonist that is hallucinogenic and disrupts 5-HT’s natural filter in the visual cortex

Answer 40

DOI

Question 41

5-HT2A antagonist

Answer 41

ketanserin

Question 42

drug that blocks choline transporters, reducing the rate of ACh production

Answer 42

hemicholinium-3 (HC-3)

Question 43

a drug that causes persistent activation of nicotinic receptors

Answer 43

carbachol

Question 44

a nicotinic receptor agonist that is a muscle relaxant used in some surgical procedures; it is resistant to breakdown by AChE and causes depolarization block

Answer 44

succinylcholine

Question 45

a nicotinic receptor antagonist that blocks receptors in both the CNS and autonomic ganglia; used to treat nicotine poisoning

Answer 45

mecamylamine

Question 46

a nicotinic receptor antagonist that blocks muscle nicotinic receptors but as relatively little effect on central receptors due to its selectively for muscle receptor and low penetrance across the BBB; used as a hunting tool by indigenous peoples; causes paralysis by preventing muscle contracts facilitated by ACh

Answer 46

D-tubocurarine

Question 47

a drug that prevents ACh from affecting DA neurons in the VTA

Answer 47

chantix

Question 48

a muscarinic receptor agonist which is a parasympathomimetic agent; poisoning leads to exaggerated parasympathetic responses such as salivation, vomiting, diarrhea, urination etc.

Answer 48

pilocarpine

Question 49

muscarinic receptor antagonists

Answer 49

atropine, scopolamine

Question 50

selective neurotoxin for 5-HT

Answer 50

5.7-DHT