Drugs test 3 Flashcards Preview

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Flashcards in Drugs test 3 Deck (16)
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1
Q

levodopa MOA

A

converted to dopamine by DOPA decarboxylase (in both the periphery and CNS) to act on D1 and D2 receptors

2
Q

levodopa SAE

A

Nausea, arhythmia, orthostatic hypotension (peripheral toxicity)

Neuropsychiatric symptoms (central toxicity)

3
Q

carbidopa MOA

A

peripheral DOPA decarboxylase inhibitor, which increases the bioavailability of levodopaand decreases the peripheral toxicities of levodopa

4
Q

catechol-O-methyltransferase (COMT) MOA

A

converts levodopa to 3-OMD in the periphery and 3-MT in the CNS (neutralizes levodopa)

5
Q

tolcapone MOA

A

peripheral and central COMT inhibitor (increases bioavailability of levodopa)

6
Q

tolcapome SAE

A

hepatotoxicity

7
Q

entacapone MOA

A

peripheral COMT inhibitor (increases bioavailability of levodopa)

8
Q

amantadine MOA

A

increases dopamine synthesis/release and inhibits uptake

9
Q

pramipexole

A

D3 receptor agonist

treat restless leg syndrome

10
Q

ropinirole

A

D2 receptor agonist

treat restless leg syndrome

11
Q

ropinirole SAE

A

may enhance impulse control disorders (gambling, shopping, hypersexuality)

12
Q

selegiline MOA

A

monoamine oxidase B inhibitor (increases dopamine levels in CNS)

13
Q

trihexyphenidyl MOA

A

M1 antagonist

improves tremor and rigidity

14
Q

Benztropine MOA

A

M1 antagonist

improves tremor and rigidity

15
Q

haloperidol MOA and uses

A

D2 receptor antagonist

chorea, psychosis, irritability

16
Q

fluphenazine MOA and uses

A

D2 receptor antagonist

chorea, psychosis, irritability