Drugs that inhibit the synthesis of cholesterol and triglycerides in the liver

Question 1

1. HMG-CoA reductase inhibitors.

1

Answer 1

А. Fungal lactones activated in the liver:
Lovastatin: reduces cholesterol by 30%, LDL by 39%.
Simvastatin: reduces cholesterol by 25-30%, LDL by 35-38%

Question 2

1. HMG-CoA reductase inhibitors. The most active hypocholesterolemic agents do not increase the TG level:
   (2)

Answer 2

B. Semisynthetic fungal lactone:

Pravastatin- reduces cholesterol by 20-25%, LDL by 25-30%

Question 3

1. HMG-CoA reductase inhibitors. The most active hypocholesterolemic agents do not increase the TG level:
   (3)

Answer 3

C. Synthetic indole derivatives:
Fluvastatin- - reduces cholesterol by 22-25%, LDL by 24-31%
Side effects : with combined use of statins and fibrates - reversible hepatitis, muscle pain, nausea, headache, sleep disorders
Indications: dyslipidemia, hypercholesterolemia and triglyceridemia

Question 4

2) Nicotinic acid drugs

Answer 4

Nicotinic acid

Enduracin

Question 5

Nicotinic acid

Answer 5

water-soluble
vitamin B group
LDL - by 15-30%, increases

Question 6

Nicotinic acid Indications:

Answer 6

any atherogenic dyslipidemia

Question 7

Nicotinic Side effects

Answer 7

(20%) irritation of the stomach, liver cells, redness and itching of the skin (correction - take 30 minutes 325 mg of aspirin)

Question 8

Nicotinic Contraindications

Answer 8

diabetes, gout, peptic ulcer, hepatitis, cardiac arrhythmias

Question 9

Enduracin

Answer 9

prolonged form of nicotinic acid
Well absorbed in the digestive tract
practically does not give adverse reactions
The effect develops after 1.5 months from the beginning of the reception, lasts 2 months after the termination of the reception

Question 10

3. Fibric acid derivatives (fibrates)

Answer 10

Indications: hypertriglyceridemia (dyslipidemia II B, III, IV
Side effects: stone formation in the biliary tract, muscle pain
Contraindications: liver disease, blood diseases (anemia, leukopenia)
Bezafibrat - reduces TG less effectively