Drugs To Know For ALS, PD, MS

Question 1

Corticosteroid to decrease inflammation
used in acute phase of MS

Answer 1

Methyprednisone

Question 2

SE: weight gain, atrophy, HTN, breakdown of muscle, bones and ligaments

Answer 2

Methylprednisone

Question 3

2 drugs for regular MS

Answer 3

Methylprednisone

Dalfampridine

Question 4

4 drugs for RRMS

Answer 4

Beta 1-a/b
Glatiramer acetate
Fingolimod
Natalizumab

Question 5

Drug for secondary progressive MS

Answer 5

Mitoxanterone

Question 6

6 drugs for parkinsons

Answer 6

Levodopa + carvidopa 
Ropinorole/prom/roti
Amantidine
Benzotropine/trihexy
Tolcapone/entac
Rasagaline/seleg

Question 7

3 drugs for ALS

Answer 7

Riluzole
Nuedexta
Radicava

Question 8

Glyburide

Answer 8

Reduces swelling after a brain injury

DONT use in elderly

Question 9

Interferons are for RRMS

 Reduces intensity and frequency of relapses

Answer 9

Beta 1-b

Question 10

side effects are fever-like Sx, GI sx, general malaise

Answer 10

Beta 1-b

Question 11

unique mechanism in the way that it works on the myelin proteins

Answer 11

Glatiramer acetate

Question 12

Immunomodulating drug for RRMS
It works by keeping immune cells trapped in your lymph nodes so they can’t reach the
central nervous system (brain and spinal cord)

Answer 12

Fingolimod

Question 13

SE: weakness, back pain, painin hands/feet, DN, ab pain, headache, hair loss

Answer 13

Fingolimod

Question 14

Made as a DMT to treat RRMS
o Modifies course of disease

o Molecule VCAM-1 (active molecule in MS) Binds to leukocytes so the drug stops
connection to CNS

Answer 14

Natalizumab

Question 15

Had to have very active Sx and atleast one relapse in the past year to be a candidate for
this med
o IV administered

Answer 15

Natalizumab

Question 16

blocks the alpha-4 subunit
on integrin molecules located with the vasculature, preventing migration and adhesion
of leukocytes to areas of tissue damage.
 By blocking this interaction, it can reduce the affects that leukocytes can have in
response to tissue damage, such as inflammation.

Answer 16

Natalizumab

Question 17

SE: abdominal, back, limb, or joint pain, diarrhea, strength and energy loss (fatigue),
headache, depression, muscle cramps, symptoms of the common cold/flu, skin rash or
other infusion related reaction, urinary tract infection, nausea, or an upper/lower
respiratory tract infection

Answer 17

Natalizumab

Question 18

Used for all kinds of MS except for PPMS

Answer 18

Mitoxantrone

Question 19

MOA: interacts with the deoxyribonucleic acid (DNA). The drug intermingles with the
DNA, causing the strands to break apart. This will decrease the effects of the
macrophages, B-cell, and T-cell proliferation and destruction of the myelin sheath2. This
reduction in the proliferation of these cells as well as the reduction of interleukin-2
proteins relate to decreased inflammation that is a result of MS

Answer 19

Mitoxantrone

Question 20

12 mg every 3 months and SE is urine color change

Answer 20

Mitoxantrone

Question 21

mainly used to regain walking ability
o NOT disease-modifying

Answer 21

dalfampridine

Question 22

Use: neurofunctional modifier; improves walking speed and LE strength in patients with
MS

Answer 22

dalfampridine

Question 23

Dosage = 10 mg 2x daily
o Immediate Sx = paraestehsia, DNV, anxiety, gait in 3%
o Slow release Sx = falls
o PT considerations = MS will fatigue; watch burning sensations, monitor closely with
vitals

Answer 23

dalfampridine

Question 24

inhibit voltage gated potassium channels is this meds MOI

Answer 24

dalfampridine

Question 25

Drug combo for PD | o to combat the main symptoms of resting tremor, rigidity, and bradykinetic movements commonly seen in Parkinson’s

Answer 25

Carbidopa/Levodopa

Question 26

Side effects is dyskinesia

Answer 26

Carbidopa/Levodopa

Question 27

Dopamine agonist to decrease PD Sx and control fluctuations  Secondary use: treat restless leg syndrome

Answer 27

Ropinorole

Question 28

Side effects of this medication include: worsening dyskinesias, extreme drowsiness, orthostatic hypotension, hallucinations, swelling of the lower legs, nausea, vomiting, dry mouth, and impulse control disorders

Answer 28

Ropinorole

Question 29

lexi-drug that can be used to treat Parkinson’s Disease and drug- induced extrapyramidal symptoms - used to help with tremors in early stages, and reduce dyskinesias in later stages

Answer 29

Amantadine

Question 30

Antiparkinson agent  Anticholinergic agents for movement disorders  Used for extrapyramidal disorders  Centrally active muscarinic antagonist used for Sx of PD

Answer 30

Anticholinergic Drugs (trihexyphenidyl; benztropine)

Question 31

Inhibits uptake of dopamine  MOA: cholinergic antagonist and histamine receptor antagonist  Possesses both anticholinergic and antihistamine effect

Answer 31

Benztropine

Question 32

Side effect is tachycardia

Answer 32

Benztropine

Question 33

used to treat the symptoms for idiopathic Parkinson’s disease. It is usually prescribed if other Parkinson’s drugs are not effective and the patient has motor fluctuations in symptoms with off times

Answer 33

Tolcapone

Question 34

side effects are diarrhea, dyskinesia, dystonia, nausea, sleepy disturbances/insomnia, muscle cramping, orthostatic instability, orthostatic hypotension (OH) and syncope  PT: observe physical appearance or sleepy

Answer 34

Tolcapone

Question 35

For PD  Improves tremors and mobility  The drug is a monoamine oxidase (MAO) inhibitor, which plays a major role in the catabolism of dopamine.

Answer 35

Rasagaline

Question 36

Side effects of the medication may include “flu like symptoms, headache, nausea, vomiting, constipation, diarrhea, dry mouth, lack of appetite, abdominal pain, weight loss, nightmares, joint pain

Answer 36

Rasagaline

Question 37

Treats adultonset of diabetes but also this medication could be used for the immediate treatment of those with brain damage as it has shown do reduce inflammation, hemorrhage, and vasogenic edema.

Answer 37

Glyburide

Question 38

SE: hypoglycemia | o Dont use in elderly

Answer 38

Glyburide

Question 39

For ALS | The most common side effects are impact to the gastrointestinal and neuromuscular system by feeling nausea and weak

Answer 39

Riluzole

Question 40

used to treat involuntary outbursts of crying or laughing in people with certain neurological disorders, including multiple sclerosis and amyotrophic lateral sclerosis o treats pseudobulbar effect

Answer 40

Nuedexta

Question 41

60 mg infusion dose -1 0 days daily and 2 weeks rest

Answer 41

Radicava

Question 42

It is thought to act as a free radical scavenger and prevent oxidative stress damage to neurones.

Answer 42

Radicava

Question 43

SE: bruising, gait disturbance, headache, skin inflammation or rash, eczema, respiratory failure, respiratory disorder, oxygen deficiency, glucose in the urine, and fungal skin infections

Answer 43

Radicava

Question 44

What does radicava have that could cause an allergic rxn esp in ppl with asthma?

Answer 44

Sodium bisulfite