Drugs to Treat ANCA Vasculitis (Iszard) Flashcards
Interstitial Nephritis which may be seen with ANCA-associated vasculitis when the vasculitis involves the renal medulla, is treated with?
Glucocorticoids
What are some patient populations in which systemic glucocorticoid administration is problematic?
1) Immunocompromised patients (HIV/AIDS)
2) Diabetics
3) Patients with active infections
What is an alkylating drug used to treat ANCA vasculitis and Goodpasture’s syndrome?
Cyclophosphamide
Cyclophosphamide is indicated to treat what condition in pediatric patients?
Minimal Change Nephrotic Syndrome
What limitation of use does cyclophosphamide have?
Treatment of nephrotic syndrome or other renal disease in adults
Cyclophosphamide is contraindicated in patients with?
Urinary outflow obstruction
What is a CD20-directed cytolytic antibody used to treat ANCA vasculitis and Goodpasture’s syndrome?
Rituximab
Rituximab is not recommended for use in patients with?
Severe active infections
What black box warning is associated with rituximab?
1) Fatal infusion reactions
2) Tumor lysis syndrome
3) Severe mucocutaneous reactions
4) Progressive multifocal leukoencephalopathy (PML)
Renal toxicity may result from a drug interaction between Rituximab and?
Cisplatin
What is an adjunct for the prevention of rejection in renal homotransplantation and in the management of rheumatoid arthritis?
Azathioprine
Post-transplant Renal transplant patients are known to have an increased risk of malignancy, predominantly?
Skin cancer
The risk of post-transplant lymphomas may be increased in patients who receive aggressive treatment with?
Immunosuppressive drugs, including Azathioprine
All immunosuppressive drug therapy should be maintained at?
Lowest effective levels
