Zidovudin
Antiviral drug_HIV
Neucleosides
Lamivudine
Antiviral drug_HIV
Nucleosides (NRTIs)
Zidovudine + Lamivudine (Combivir)
given after accidental needle stick
Efavirenz
Antiviral drug_HIV
Nonnucleosides (NNRTIs)
Atazanavir
Antiviral drug_HIV
Protease inhibitor prevent formation of new viral particles
Fosamprenavir
Antiviral drug_HIV
Protease inhibitor; prodrug of amprevavir
Enfuvirtide
Antiviral drug_HIV
Fusion inhibitor block the binding of HIV to CD4 lymphocytes receptors that is required for HIV to enter cells
Raltegravir
Antiviral drug_HIV
Integrase inhibitor prevent integration of viral DNA into the DNA of the infected cells
2 RT inhibitor + 1 protease inhibitor
most effective tx of HIV
Amantadine
Antiviral_Influenza
Influenza type A infection prevention and treatment
Zanamivir
Antiviral drug_Neuraminidase inhibitors
Influenza A and B infection prevention and treatment
Acyclovir
Antiviral_Herpes
Herpes simplex type 1 and 2 (HSV-1, HSV-2)Varicella zoster virus (VZV), Epstein-Barr virus (EBV), Cytomegalovirus (CMV)- mono
*TOPICAL, IV, ORALLY for herpes infections
Foscarnet
Antiviral_herpes
approved for CMV retinitis, acyclovir-resistant HSV and VZV infections
Gancyclovir
Antiviral_herpes
Drug of choice for Cytomegalovirus infections
Aedefovir
Antiviral_hepatic viral
Hep B virus
Tenofovir
Antiviral_hepatic viral
Hep B virus
Pegylated interferon
Antiviral_hepatic viral
Hep B virus
inhibit viral RNA translation
Lamivudine
Antiviral_hepatic viral
Hep B virus
inhibitor of HBV DNA polymerase and HIV reverse transcriptase
Pegylated interferon alpha-2a
Antiviral_hepatic viral
Hep C infection
Pegylated interferon alpha-2b
Antiviral_hepatic viral
Hep C infection
Ribavirin
Antiviral_hepatic viral
Hep C infection
Cyclophosphamide
Anticancer drug
Most commonly used alkylating agent
u/e Cyclophosphamide
hemorrhagic cystitis
6-mercaptopurine
Anticancer drug
Antimetabolites
5-flurouracil
Anticancer drug
Antimetabolites
Methotrexate
Anticancer drug
Antimetabolites
Psoriasis, severe active rheumatoid arthritis in addition to whole variety of cancers*administered intrathecally
Doxorubicin
Anticancer drug
Antibiotics
u/e Doxorubicin
Cardiotoxicity, alopecia and bone marrow depression
Bleomycin
Anticancer drug
Antibiotics
u/e Bleomycin
fatal pulmonary fibrosis
*extreme caution- preexisting history of lung disease
Plicamycin
Anticancer drug
Antibiotics
tx. Life-threatening hypercalcemia associated with malignancy
Vincristine
Anticancer drug
Microtubule inhibitor
u/e Vincristine
neurologic toxicity
Vinblastine
Anticancer drug
Microtubule inhibitor
u/e Vinblastine
bone marrow toxicity
Anastrozole
Anticancer drug
Hormonal agent_aromatase inhibitor
tx. estrogen-dependent breast cancer resistant to tamoxifen
Tamoxifen
Anticancer drug_Antiestrogen
tx. estrogen receptor positive breast cancer
* competitive antagonists of estrogen receptor
Flutamide
Anticancer drug_androgen receptor antagonist
tx. prostate cancer
Leuprolide
Anticancer drug_GnRh analog
tx. metastatic prostatic cancer
Rituximab
Anticancer drug_monoclonal antibodies
tx. chronic lymphocytic leukemia
Imatinib
Anticancer drug_other
tx. chronic myeloid leukemia
Geftinib
Anticancer drug_other
tx. non small cell lung cancer
Etoposide
Anticancer drug_other
tx. small cell carcinoma of the lungs
Cisplatin and Cardbaplatin
Anticancer drug_other
tx. testicular carcinoma, ovarian carcinoma, bladder carcinoma
Procarbazine
Anticancer drug_other
tx. Hodgkin’s disease
L-asperginase
Anticancer drug_other
tx. childhood acute lymphocytic leukemia (ALL)
Bacille Calmette-Guerin (BGC) vaccine
TB vaccine, effective in treating small localized superficial urinary bladder carcinomaIntravesicular use
Non-specific stimulant of the reticuloendothelial system
Asprin
Anti-inflammatory drug
Non selective inhibitors of cyclooxygenase
u/e Asprin
Reye syndrome if given in viral infections, especially in children
Diclofenac
Anti inflammatory drug
Non-selective inhibitors of cyclooxygenase
Indomethacin
Anti inflammatory drug
Non selective inhibitors of cyclooxygenase
tx. in patent ductus arteriosus (PDA) in new born babies
Celocoxib (Celebrax)
Anti inflammatory drug_selective COX-2 inhibitor
lower risk for GI bleeding, good for chronic use
u/e Celocoxib (Celebrex)
hypertention
Rofecoxib (Vioxx)
Anti inflammatory drug_selective COX-2 inhibitor
Withdrawn?
Acetaminophen
Anti inflammatory drug_analgesics
antipyretic, analgesic; weak anti inflammatory activity
Infliximab
Anti inflammatory drug_arthritis
tx. Crohn’s disease
Methotrexate
Anti inflammatory drug
disease-modifying anti-rheumatic drug
D-Penicillamine
Anti inflammatory drug
disease-modifying anti-rheumatic drug
also tx. heavy metal poisoning, Wilson’s disease
Aliopurinol
Goutreduce uric acid formation
Colchicine
tx. acute attack of gout
Probenecid
Gout drug_uricosuric drug
increase uric acid excretion by the KD
Cyclosprorine (CsA)
Immunosuppressive drug_selective inhibitors of cytokine production and fx
Prevention and treatment of transplanted organ rejections
u/e Cyclosprorine (CsA)
nephrotoxicity, thromboembolism, neurotoxicity, seizure etc.
Azathioprine
Immunosuppressive drug_immunosuppressive antimetabolites
t-cells and b-cells are particularly affected by the inhibition of purine synthesis
Mycophenolate mofetil
Immunosuppressive drug_immunosuppressive antimetabolites
inhibits an enzyme that helps the growth of Tcells and Bcells