Dyslipidemia

Question 1

4 Statin Benefit Groups

Answer 1

1. Clinical ASCVD “Secondary Prevention”
2. LDL-C > 190mg/dL without secondary cause (intake of saturated/trans fat, drugs, certain diseases)
3. Primary Prevention with DM: Age 40-75, LDL-C 70-189mg/dL
4. Primary Prevention without DM: Age 40-75, LDL-C 70-189mg/dL, estimated ASCVD risk>=7.5%

Question 2

Which anti DM drug has the best evidence base for cardiovascular event reduction?

Answer 2

Metformin

Question 3

First Line therapy for Dyslipidemia

Answer 3

Statins

Question 4

Normal total cholesterol level

Answer 4

<200

Question 5

Normal Triglycerides level

Answer 5

<150

Question 6

Normal LDL level

Answer 6

<100

Question 7

Normal HDL level

Answer 7

> 45-50

Question 8

Anti-dyslipidemic Drug - reduces LDL but may INCREASE TRIGLYCERIDES

Answer 8

Bile Acide Sequestrants (Cholestyramine)

Question 9

First line treatment for severe hypertriglyceridemia

Answer 9

Fibrates (Fenofibrate, Gemfibrozil)

reduces triglycerides by 35-50%

Question 10

Anti-dyslipidemic Drug - increases HDL but may cause gout and flushing

Answer 10

NIACIN

Question 11

Anti-Dyslipidemic Drug - inhibits cholesterol absorption by 60%

Answer 11

EZETIMIBE

Question 12

Statins reduce LDL by how much?

Answer 12

20-60%

Question 13

Most common AE of Statins

Answer 13

Hepatotoxicity

Question 14

Most important reason for using statins

Answer 14

Greatest mortality benefit

Question 15

Results to increased risk of myopathy

Answer 15

Statins + Gemfibrozil

Question 16

MOA: Inhibits bile acid absorption

Answer 16

Cholestyramine

Question 17

MOA: upregulate lipoprotein lipase to increase breakdown of VLDL and chylomicrons

Answer 17

Fibrates