Dyslipidemia Flashcards
(113 cards)
1
Q
cholesterol is an important component of healthy cells and tissues including the brain. It is a component of cell walls and a precursor in hormone synthesis. Also is used in the production of bile acids. It is when cholesterol levels are in elevated states that put us at risk for ___________
A
cardiovascular and other disease
2
Q
Bile acids are needed to __________. Bile acids are produced __________ and then travel through the bile ducts into __________. This is where bile acids are converted to __________ which are then recycled and returned to _______
A
absorb lipids, including fat-soluble vitamins.
in the liver.
the small intestine
bile salts
the liver
3
Q
The process enterohepatic recycling involves the __________ and the __________
A
gut (enteric system)
liver (hepatic)
4
Q
Atherosclerosis: is _____
A
the formation of plaque from the buildup of fats, cholesterol and other substances on the inner walls of arteries
5
Q
Atherosclerosis although asymptomatic, leads to ______________, which includes ___________.
Different types of cholesterol either __________from or contribute to ASCVD risk
A
(ASCVD) atherosclerotic cardiovascular disease
myocardial infarction, stroke/transient ischemic attacks, angina and peripheral arterial disease.
protect
6
Q
Cholesterol in the body can be decreased by:
1)
2)
3)
A
reducing the formation (like with statins)
blocking absorption (ezetimibe)
blocking enterohepatic recirculation of bile salts (bile acid sequestrants like colesevelam)
7
Q
Lipids in the body are transported via _________. they are not transported by themselves. These types of lipoproteins are what we call are types of ________
A
lipid proteins
cholesterol or types of lipids
8
Q
LDL
what level is desirable?
what level is very high?
In someone with diabetes or ASCVD we want to target a lower level. what level is desirable in this case?
A
Low-density lipoprotein “bad cholesterol”
we want low
- < 100mg/dL is desirable
- > or = 190mg/dL is very high
In someone with diabetes or ASCVD we want to target a lower level.
We want a level < 70 mg/dL
9
Q
HDL
what level is normal in men?
what level is normal in women?
A
High density lipoprotein “good cholesterol”
we want high
> 40mg/dL is normal in men
50mg/dL is normal in women
10
Q
VLDL
A
Very-low density lipoproteins
-these carry TG
11
Q
Total cholesterol:
A
LDL + HDL + VLDL + TG
12
Q
Non-HDL:
what level is desirable?
A
total cholesterol - HDL
< 130 mg/dL id desirable
13
Q
elevations in cholesterol increase risk for _________________ due to fat accumulation in the arteries.
A
atherogenic disease (tending to promote the formation of fatty plaques in the arteries)
14
Q
Dyslipidemia:
A
abnormality in lipoprotein levels
15
Q
Primary (or familial) hypercholesterolemia:
A
inherited (genetic defect), severe cholesterol elevations
heterozygous familial hypercholesterolemia (HeFH)
homozygous familial hypercholesterolemia (HoFH)
16
Q
Secondary (or acquired) dyslipidemia:
A
“what we normally are thinking of, things that can cause high levels of fat in the body”
happens from
-Diet
-Diseases like obesity, hypothyroidism, nephrotic syndrome, biliary obstruction
-Drugs
17
Q
Key Drugs that increase cholesterol: they can raise LDL AND (TG)
triglycerides
A
diuretics
efavirenz
steroids
immunosuppressants (cyclosporine & tacrolimus)
atypical antipsychotics
protease inhibitors
retinoids
18
Q
Key drugs that increase LDL only:
A
Fish Oils (except Vascepa)
fibric acids
SGLT2 inhibitors
thiazolidinediones
anabolic steroids
fibrates
progestins
19
Q
Key drugs that increase TG only:
A
IV lipid emulsions
Propofol
Bile acid sequestrants
alcohol
estrogen
tamoxifen
clevidipine
beta-blockers
20
Q
Lipid panels are taken after a _________. If the LDL isn’t reported, it can be calculated using _____________.
We cannot use this equation when _______________
A
9-12 hour fast
Friedewald equation: LDL = TC - HDL - (TG/5)
TGs > 400mg/dL
21
Q
when should medications be considered when just looking at a patients LDL level?
A
if the LDL is > or equal to 190 mg/dL, then medications should be considered in a patient.
22
Q
when triglyceride levels hit ____________, that is when we are worried about starting treatment for triglyceridemia and are worried about causing _____________
A
> or equal to 500 mg/dL this is very high
pancreatitis, if we do not get triglycerides down.
23
Q
Non-drug treatment for dyslipidemia includes:
A
Diet: personalized diet to individual patient, to maintain a healthy weight (BMI 18.5-24.9 kg/m2)
-eating vegetables, fruits, whole grains, low fat dairy, poultry, fish, legumes, nuts
-limit sugared beverages, sweets
-Aim for 5-6% calories from saturated fat, limit trans fat
Exercise: moderate-to-vigorous physical exercise 3-4 x/week lasting 40 minutes/session
Avoid tobacco products and limit alcohol consumption.
24
Q
What are natural products that may lower cholesterol levels?
A
25
Treatment Principles
*Reducing the risk of the patient
26
Statin Treatment: 4 groups that benefit most from statin therapy.
what are these groups?
1) Clinical ASCVD
2) Primary elevations of LDL > or equal to 190 mg/dL
3) Diabetes & age 40-75 years old with an LDL 70-189 mg/dL
4) Age 40-75 years old with LDL 70-189 mg/dL
27
what are the criteria for patients with clinical ASCVD and what statin treatment is recommended in this group?
patient criteria for clinical ASCVD: "already had an event" so at much greater risk of another.
- (CHD) coronary heart disease which includes: (ACS) Acute Coronary Syndromes - MI, stable or unstable angina, coronary or other arterial revascularization like a stent to open up an artery, stroke = (TIA) transient ischemic attack. (PAD) peripheral artery disease
(Secondary prevention)
statin treatment: High intensity
28
what are the criteria for patients with primary elevations of LDL > or = to 190 mg/dL and what statin treatment is recommended in this group?
patient criteria: any age
statin treatment: High intensity
29
what are the criteria for patients with diabetes & age 40-75 years old with an LDL between 70 - 189 mg/dL? What statin treatment is recommended in this group?
Regardless of ASCVD risk ------------ moderate intensity statin
If multiple ASCVD risk factors --------- High intensity statin
30
what are the criteria for patients aged 40-75 years old with an LDL between 70-189 mg/dL? what statin treatment is recommended in this group?
IF ----- 10-year ASCVD risk is > or = to 20% then High intensity statin
if ---- 10-year ASCVD risk is 7.5-19.9% + patient has risk-enhancing factors then Moderate intensity statin
31
what are ASCVD risk factors?
they are the same things that go into an ASCVD risk score but we are not using the risk score in these patients.
gender
age
TC
HDL
systolic blood pressure, is antihypertensive treatment being used
is diabetes present
smoking status
32
what are the high intensity statins and doses?
what does it mean to be on a high intensity statin?
Atorvastatin 40mg - 80mg
Rosuvastatin 20mg - 40mg
A High intensity statin will decrease LDL on average 50% or greater
33
what are the moderate intensity statins and doses?
what dose it mean to be on a moderate intensity statin?
Pitavastatin 1-4mg
Rosuvastatin 5-10mg
Atorvastatin 10-20mg
Simvastatin 20mg - 40mg
Lovastatin 40mg
&
Pravastatin 40-80mg
Fluvastatin 80mg (either 40mg bid for IR or 80mg XL)
"Pharmacist Rock At Saving Lives & Preventing Fats"
A moderate intensity statin will decrease LDL on average 30-49%
34
What are the low intensity statins and doses?
what does it mean to be on a low intensity statin?
Simvastatin 10mg
Pravastatin 10mg-20mg
Lovastatin 20mg
Fluvastatin 20-40mg
A low intensity statin will decrease LDL on average less than < 30%
35
CAC = _____
Coronary Artery Calcium score:
- a score > or equal to 100 Agatson units indicates statins should be initiated
36
If LDL is still above 70 mg/dL despite patient being on a high intensity statin then consider _______
Zetia ($)
or PCSK9 inhibitor ($$$)
37
Calculating ASCVD Risk
What are those components to calculate the 10-year risk?
*if patient has already had an event, then we DO NOT USE calculator. Calculator is for primary prevention.
Sex
Age (20-79)
total cholesterol
HDL-c
SBP (treatment Y or N)
Smoking (Y or N)
Race (white or other)
Diabetes (Y or N)
38
Statin medications
Indications:
MOA:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
MOA: inhibit the rate-limiting step of cholesterol synthesis
Lipid effects:
- decrease LDL 20-55%, increase HDL 5-15%, decreased TG 10-30%
Contraindications:
- active liver disease
- pregnancy category X " meaning absolutely DO NOT USE"
- breastfeeding
-taking concurrent strong 3A4 inhibitors (simvastatin, lovastatin)
Side effects:
myalgias, arthralgias, myopathy, increase CPK, rhabdomyolysis (break down of muscle), blood glucose elevations, increase A1C, increased risk of cataracts, increased LFTs,
Renal considerations:
Reduce dose when CrCl < 30mL/min, except with Lipitor. When CrCl < 60mL/min reduce Livalo dose
39
Statins & Myalgias
-statins can cause muscle damage with varying severity
Myalgia:
Myopathy:
Myositis:
Rhabdomyolysis:
Management of Myalgias
Reduce the risk
-
-
-
Myalgia: muscle soreness/tenderness, "think pain" a very general feeling of weakness, tiredness,
Myopathy: muscle weakness (+/-) with or without CPK elevation, more
Myositis: muscle inflammation
Rhabdomyolysis: muscle symptoms + CPK elevation (severe elevations), which can lead to acute renal failure
-Avoid drug interactions
-Do NOT Use simvastatin 80mg/day
-Do not combine gemfibrozil + statin
**Manage symptoms**
-hold statin, check CPK
-After 2-4 weeks: rechallenge with same statin at same or lower dose
-If myalgias return, discontinue statin
- once symptoms resolve, try a low dose of a different statin and gradually increase the dose.
40
What biomarker is used to determine muscle damage?
CPK
41
Lipitor*
Class
Indications
Dosing
MOA
Contraindications
Warnings
Side effects
Monitoring
Notes/Pearls
Drug-Drug interactions:
atorvastatin
Class: Statin
Indications: Dyslipidemia
Dosing: 10-80mg daily
MOA: inhibits the enzyme HMG-CoA reductase (3-hydroxy-3-methylglutaryl coenzyme A reductase), which prevents the conversion of HMG-CoA to mevalonate. "Inhibiting the rate-limiting step in cholesterol synthesis"
Lipid effects:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
42
Caduet
atorvastatin + amlodipine
43
Lescol
fluvastatin
Class:
Indications:
Dosing:
MOA:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
44
Altoprev*
lovastatin
Class:
Indications:
Dosing:
MOA:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
45
Mevacor**
lovastatin brand D/C
Class:
Indications:
Dosing:
MOA:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
46
Livalo
pitavastatin
Class:
Indications:
Dosing:
MOA:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
47
Zypitamag
pitavastatin
Class:
Indications:
Dosing:
MOA:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
48
Pravachol
pravastatin
Class:
Indications:
Dosing:
MOA:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
49
Crestor
rosuvastatin
Class:
Indications:
Dosing:
MOA:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
50
Zocor
simvastatin
Class:
Indications:
Dosing:
MOA:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
51
FloLipid
simvastatin
Class:
Indications:
Dosing:
MOA:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
52
Zetia
ezetimibe
Class:
Indications:
Dosing:
MOA:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
53
Vytorin
ezetimibe + simvastatin
Class:
Indications:
Dosing:
MOA:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
54
Praluent
alirocumab
Class:
Indications:
Dosing:
MOA:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
55
Reptha, Reptha SureClick
evolocumab
Class:
Indications:
Dosing:
MOA:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
56
Pushtronex
evolocumab
Class:
Indications:
Dosing:
MOA:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
57
Prevalite
cholestyramine
Class:
Indications:
Dosing:
MOA:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
58
Questran*
Questran Light*
cholestyramine Brand D/C
Class:
Indications:
Dosing:
MOA:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
59
Welchol
colesevelam
Class:
Indications:
Dosing:
MOA:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
60
Colestid
colestipol
Class:
Indications:
Dosing:
MOA:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
61
Antara
fenofibrate
Class:
Indications:
Dosing:
MOA:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
62
Tricor
fenofibrate
Class:
Indications:
Dosing:
MOA:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
63
Trilipix
fenofibrate
Class:
Indications:
Dosing:
MOA:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
64
Lopid
gemfibrozil
Class:
Indications:
Dosing:
MOA:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
65
Niacor
niacin IR
66
Niaspan
niacin ER
67
Slo-Niacin
niacin CR/SR
68
Lovaza
omega-3 acid ethyl esters
Class:
Indications:
Dosing:
MOA:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
69
Vascepa
icosapent ethyl
70
Juxtapid
lomitapide
Class:
Indications:
Dosing:
MOA:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
71
What are the equivalent statin doses?
Which statin is the most potent on a mg basis?
Which statin is the most potent agent to lower LDL-C?
Pitavastatin 2mg = Rosuvastatin 5mg = Atorvastatin 10mg = Simvastatin 20mg = Lovastatin 40mg = Pravastatin 40mg = Fluvastatin 80mg
Pitavastatin
Rosuvastatin
72
How to remember statin toxicities?
Think of the MOA: HMG CoA reductase inhibitors
Hepatotoxicity
Myalgia, Myositis, rhabdomyolysis
Glucose changes
73
Which Statins have specific dosing requirements?
Simvastatin
Lovastatin IR - must also be taken with evening meal
Fluvastatin
"must be taken in the evening"
74
Simvastatin and Lovastatin are Contraindicated with strong CYP3A4 inhibitors: & gemfibrozil & conivaptan
examples of drugs/classes include:
itraconazole
ketoconazole
posaconazole
voriconazole
erythromycin-macrolides not azithromycin
clarithromycin
HIV protease inhibitors
Cobicistat-containing regimens
Nefazodone
Cyclosporine
Danazol (w/ simvastatin)
Grapefruit juice
75
what is the Max dose of Simvastatin if patient needs to also be on verapamil?
Max 10mg/day
76
what is the Max dose of Simvastatin if patient needs to also be on diltiazem?
Max 10mg/day
77
what is the Max dose of Simvastatin if patient needs to also be on lomitapide?
Max 20mg/day
78
what is the Max dose of Simvastatin if patient needs to also be on ranolazine?
Max 20mg/day
79
what is the Max dose of Simvastatin if patient needs to also be on ticagrelor?
Max 40mg/day
80
what is the Max dose of Simvastatin if patient needs to also be on amlodipine?
Max 20mg/day
81
what is the Max dose of Simvastatin if patient needs to also be on amiodarone?
Max 20mg/day
82
what is the Max dose of Simvastatin if patient needs to also be on dronedarone?
Max 10mg/day
83
what is the Max dose of lovastatin if patient needs to also be on danazol?
Max 20-40mg/day
84
what is the Max dose of lovastatin if patient needs to also be on diltiazem?
Max 20mg/day
85
what is the Max dose of lovastatin if patient needs to also be on dronedarone?
Max 20-40mg/day
86
what is the Max dose of lovastatin if patient needs to also be on verapamil?
Max 20mg/day
87
what is the Max dose of lovastatin if patient needs to also be on amlodipine?
Max 20-40mg/day
88
what is the Max dose of lovastatin if patient needs to also be on amiodarone?
Max 40mg/day
89
what is the Max dose of lovastatin if patient needs to also be on ticagrelor?
Max 20-40mg/day
90
Zetia
ezetimibe
Class:
Indications:
Dosing: 10mg daily
MOA: inhibits absorption of cholesterol in the small intestine at the brush border.
Lipid effects: decreases LDL 18-23%, increases HDL 1-3%, decreases TG 5-10%
Contraindications:
Warnings: Avoid use in moderate or severe hepatic impairment
Skeletal muscle effects are increased when combined with a statin (myopathy, including risk of rhabdomyolysis)
Side effects: Upper Respiratory Tract Infections (URTIs), diarrhea, arthralgias, myalgias, pain in extremities, sinusitis
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
91
What Study showed that the addition of ezetimibe to moderate intensity statin therapy in stable patients with recent ACS further lowered the risk of CV events.
IMPROVE-IT study
92
Vytorin
ezetimibe + simvastatin
93
(BAS) Bile Acid Sequestrants
Indications:
MOA:
Lipid effects:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
Indication:
MOA: Bind bile acids in the intestines, forming a complex, that is excreted in the feces
Lipid effects: decrease LDL 10-30%, increase HDL 3-5%, increase TG ~5%
Contraindicated:
Side effects: constipation, abdominal pain, cramping, gas, bloating, hypertriglyceridemia, esophageal obstruction, increased LFTs, dyspepsia, nausea
Drug-Drug interactions: Not to common except for the thought of binding and removing it.
Just need to be cautious and separate all drugs by 1-4 hours before or 4-6 hours after. To prevent the binding and removing of other drugs.
94
Questran
Questran Light
cholestyramine
Indications:
Class: bile acid sequestrant
MOA:
Lipid effects:
Contraindications: complete biliary obstruction
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
95
Prevalite
cholestyramine
Indications:
Class:
MOA:
Lipid effects:
Contraindications: complete biliary obstruction
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
96
Welchol
colesevalam
Indications:
*does have an approval for diabetes
Class:
MOA:
Lipid effects:
Contraindications: bowel obstruction, TG > 500mg/dL, Hx-induced pancreatitis
*remember TG above 500 mg/dL increases risk for pancreatitis
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
97
Colestid
colestipol
Indications:
Class:
MOA:
Lipid effects:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
98
We would not want to start a Bile acid sequestrant in a patient if the Triglyceride levels are ________________
greater than or equal to 300mg/dL
99
Fibrates
Indications: for high triglycerides
Class:
MOA:
Lipid effects:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
So if triglycerides are high > 500mg/dL, we can use these.
agonists for the nuclear transcription factor (PPAR alpha) peroxisome proliferator-activated receptor alpha.
MOA: they eliminate and decrease synthesis of VLDL and TGs and increase HDL
*remember VLDLs carry TGs*
Lipid effect: decrease TGs 20-50%, increase HDL 15%, decrease LDL 5-20% (however can increase LDL when TGs are high)
Contraindications:
-severe liver disease
-severe renal disease
-gallbladder disease (CrCl < 30mL/min)
-nursing mothers
Side Effects:
- increased LFTs (dose-related)
- increased CPK
-myopathy
-dyspepsia
-increased SCr (transient = only lasting a short time)
-cholelithiasis (rare)
-risk or myopathy is increased when given with a statin, especially in elderly, diabetes, renal impairment or hypothyroidism
100
Lopid
gemfibrozil
indications:
Class:
MOA:
Lipid effects:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls: Giver 30 minutes before breakfast and dinner
Drug-Drug Interactions:
101
Antara
fenofibrate
Indications:
Class:
MOA:
Lipid effects:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
102
TriCor
fenofibrate
Indications:
Class:
MOA:
Lipid effects:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
103
Trilipix
fenofibrate
Indications:
Class:
MOA:
Lipid effects:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
104
Fibricor
fenofibrate
Indications:
Class:
MOA:
Lipid effects:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
105
Triglide
fenofibrate
Indications:
Class:
MOA:
Lipid effects:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
106
Lipofen
fenofibrate
Indications:
Class:
MOA:
Lipid effects:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls: Take with food
Drug-Drug Interactions:
107
Fenoglide
fenofibrate
Indications:
Class:
MOA:
Lipid effects:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls: Take with food
Drug-Drug Interactions:
108
Niacin
109
Niacin
immediate release niacin =
extended-release niacin =
controlled release or sustained release niacin =
Indications:
Class:
MOA:
Lipid effects:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls: "Flush free products do not work"
Do NOT use if LFTs are 3x the Upper limit of normal
Drug-Drug Interactions:
Lipid effects: lower LDL 5-25%, increase HDL 15-35%, decrease TG 20-50%
we use for the TG effects
IR = Niacor
very significant flushing, can decrease this by taking aspirin or an NSAID before the dose
ER = Niaspan
CR or SR = Slo-Niacin
using an ER or CR/SR will also decrease the flushing, however have an increased risked of liver toxicity
Contraindications:
-active liver disease
-active PUD peptic ulcer disease
-arterial bleeding
Side effects:
Flushing, pruritus, diarrhea, GI upset, hyperglycemia, hyperuricemia, hepatotoxicity
Monitor:
-LFTs at baseline and every 6-12 weeks for the first year
-watch for ineffective preparations
-take with food - avoid hot liquids and spicey food
110
Fish Oils
Omega-3 Acid Ethyl Esters =
Icosapent ethyl =
Omega-3 carboxylic acids =
Indications:
Class:
MOA:
Lipid effects:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
Indicated as an adjunct to diet in patients with TGs > or equal to 500 mg/dL
"we use for treating TGs"
Lipid effects: decrease TG up to 45%, increase HDL 9%, may increase LDL (not vascepa)
Omega-3 Acid Ethyl Esters = Lovaza (EPA + DHA)
Icosapent ethyl = Vascepa (pure EPA)
Omega-3 carboxylic acids = Epanova
Side effects: eructation, taste perversions (Lovaza, Epanova), arthralgias (Vascepa)
Prolonged bleeding time
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(PCSK9 inhibitors) = Proprotein convertase subtilisin Kexin type 9 inhibitors
Indications:
Class:
MOA:
Lipid effects:
Contraindications:
Warnings:
Side effects:
Monitoring:
Note/Pearls:
Drug-Drug Interactions:
In the body: PCSK9 binds to LDL receptors, causing LDL receptors to degrade
PCSK9 inhibitors: Human monoclonal antibodies that bind & block the PCSK9 from binding to receptors, preventing LDL receptor degradation, increasing available LDL receptors available.
- with LDL receptor present longer we get increased LDL clearance and lower LDL levels
Lipid Effects: decreases LDL ~60%, decreases non-HDL 35%, decreases ApoB ~50%, decreases TC ~36%
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Praluent
alirocumab
Indication: heterozygous familial hypercholesterolemia (HeFH) or ASCVD on max statin dose in needed of additional LDL lowering
Dose: 75-150mg SC every 2 weeks
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Repatha
evolocumab
Indication:
-Homozygous familial hypercholesterolemia on max statin to reduce LDL
-primary hyperlipidemia (including HeFH) to reduce LDL
-prevention of cardiovascular events in patients with ASCVD (so patients who had an event previously)
Dose: 140mg SC every 2 weeks or 420mg SC every month (4 weeks)
Side Effects: nasopharyngitis, injection site reactions, influenza; URTIs, UTI, and back pain (evolocumab), increased LFTs (alirocumab)
