Dyspepsia drugs Flashcards
1
Q
What does triple therapy for H Pylori eradication consist of
A
- PPI
- Amoxicillin
- Clarithromycin/ metronidazole
2
Q
What does quadruple therapy for H Pylori eradication consist of
A
- PPI
- Tetracycline
- Metronidazole
- Bismuth chelate
3
Q
How do PPIs work
A
Inhibit H+/K+ ATPase
^which normally secretes H+ from parietal cells
4
Q
How to H2 receptor antagonists (eg Cimetidine, Ranitidine) work
A
Competitive antihistamine at H2 receptor
5
Q
How do antacids work
A
- Raise stomach pH to neutralise stomach acid
2. Bind to and inactivate pepsin
6
Q
Is cimetidine a CYP450 inhibitor or inducer
A
Inhibitor
so don’t give with warfarin otherwise bleeding risk
7
Q
1st line treatment for peptic ulcer disease
A
H2 receptor antagonist
8
Q
Long term risks of PPI
A
Osteoporosis
Vit B12 deficiency
Increased risk of pneumonia, bowel infections, MI, dementia
