E1: STI Part 2 Flashcards

1
Q

What is PID?

A

An infection of the upper genital tract (ascending infection
-represents a spectrum of infection (any combination of endometriosis, salpingitis, oophoritis, peritonitis, etc

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2
Q

What is the etiology of PID/

A

Majority are N. Gonorrhoeae or C. Trachomatis, or BV associated pathogens
-Mycoplasma is emerging

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3
Q

What populations are at risk for PID?

A
  • Women with multiple sex partners
  • Age < 25
  • Partner with an STI
  • Hx of PID or STI
  • IUD
  • Disruption of normal vaginal flora
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4
Q

What is the clinical presentation of PID?

A

-range from mild, vague pelvic symptoms to tube-ovarian abscess, sepsis, and possibly perihepatitis

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5
Q

What is Fitz-Hugh syndrome?

A
  • Perihepatitis, inflammation of the liver capsule and adjacent peritoneal structures
  • Characterized by RUQ pain and “violins string” adhesions of the liver
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6
Q

Patient presents with lower abdominal pain that occurs after mentees, abnormal vaginal discharge, abnormal bleeding, dyspareunia, and a fever. On PE, patient has abdominal pain in the lower quadrants, and pelvic exam has a positive chandelier sign and purulent endocervical discharge. What is the most likely diagnosis?

A

PID

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7
Q

What is Chandelier sign?

A

Uterine, adnexal, and/OR CMT

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8
Q

What is the outpatient treatment of mild-moderate PID?

A

Ceftriaxone 250mg IM single dose PLUS doxy 100mg BID x 14 days
With or without metronidazole 500mg PO BID x14 days

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9
Q

When should you hospitalize for PID?

A
  • Pregnancy
  • lack of response or tolerance to oral medications
  • concern for non adherence to therapy
  • inability to take oral meds
  • severe clinical illness
  • complicated PID
  • Surgical emergencies
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10
Q

What are the possible complications of PID?

A
  • Hydrosalpinx
  • infertility
  • risk of ectopic pregnancy
  • chronic pelvic pain
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11
Q

What is the most common STI in the world?

A

HPV

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12
Q

What types of HPV are detected in most cases of condyloma acuminata?

A

6 and/or 11 (low oncogenes potential

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13
Q

What are the types of HPV that have high oncogenic potential?

A

16 and 18

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14
Q

What are the risk factors for HPV?

A
  • Sexual activity
  • smoking
  • immunosuppresion
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15
Q

What is the clinical presentation of Condyloma Acuminata (AKA anogenital wart)?

A
  • Typicall asymptomatic, but may be pruritic
  • soft flesh colors smooth or plaque like
  • single, multiple, flat, dome shaped, cauliflower, etc
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16
Q

How is Condyloma acuminata diagnosed?

A
  • Visualize warts on exam

- biopsy may be considered if dx is uncertain

17
Q

What is the treatment of condyloma acuminata?

A
  • Cyto-destructive (podofilox, trichloracetic acid)
  • Immune-mediated (Imiquimod, Sinecatechins)
  • Surgical (cryotherapy, laser, electrocautery)
18
Q

How can HPV be prevented?

A
  • HPV vaccine!!
  • Condoms used consistently and correctly can lower the changes of acquiring and and transmitting
  • Limiting number of sex partners
19
Q

What are most cases of recurrent genital herpes caused by?

A

HSV2

20
Q

70% of genital herpes transmission occurs during times of ***.

A

Asymptomatic HSV shedding

21
Q

What is a primary episode of genital herpes?

A
  • Infection in a patient without preexisting antibodies to either HSV1 or HSV2
  • longer duration, increased viral shedding, and systemic symptoms
  • symptoms may last 2-4 weeks if untreated
22
Q

What is a non-primary first episode of genital herpes?

A
  • Acquisition of genital HSV2 in a patient with preexisting antibodies to HSV1
  • symptoms usual milder than primary infection
23
Q

What is the clinical presentation of a primary infection of genital herpes?

A
  • Average incubation period after exposure is 2-12 days
  • painful genital ulcers, dysuria, fever, tender inguinal lymphadenopathy, headache
  • possible to be asymptomatic
24
Q

What is the clinical presentation of a recurrent infection of genital herpes?

A
  • Prodromal symptoms before the eruption

- symptoms tend to be less severe than primary infection

25
Q

How is genital herpes diagnosed?

A
  • Virologic tests are preferred (viral culture)
  • PCR
  • Serologic tests (tests for antibodies, may be false negatives in early disease)
26
Q

What does presence of HSV2 antibody imply?

A

Anogenital infection

27
Q

What does presence of HSV1 antibodies imply?

A

-consistent with either anogenital or orolabial infections

28
Q

What is the treatment for genital herpes?

A

-Valacylovir, famciclovir, or acyclovir
-first episode: 7-10 day regimen started within 72 hours
-Recurrent outbreaks: 1-5 day regimens
Suppression: Once a day or BID dosing