E2F MG Dev

Question 1

Describe the pattern of STAT3 activity during MG development.

Answer 1

STAT3 pathway activation is low until the onset of involution, at which point STAT3 pathway activity is very high.

Note: Expression of STAT3 only slightly changes. Phosphorylation of STAT3 is crucial in regulating this mechanism.

Question 2

Describe the activity of p63 during lactation.

Answer 2

Activation of the p63 pathway is elevated during lactation.

Question 3

Describe the activity of E2F1-3 in mammary gland development.

Answer 3

E2F1-3 pathway signatures are elevated during pregnancy and decreased during involution.

E2F1 and E2F3 are active during proliferation during pregnancy but not during lactation.

Question 4

Describe the activity of E2F4 in mammary gland development.

Answer 4

The E2F4 pathway activity is roughly the inverse of E2F1-3.

E2F4 activity is elevated during involution, early puberty, and adult virgin.

E2F4 activity is low during pregnancy and lactation.