EBV

Question 1

What is EBV?

Answer 1

Also called infectious mononucleosis or glandular fever
Viral infection - member of the Herpesviridae family

Question 2

What is the key epidemiology of EBV infection?

Answer 2

Young adults in developed countries

Question 3

What are the key signs and symptoms of an EBV infection?

Answer 3

Asymptomatic
Fever and general malaise
Sore throat
Transient macular rash
Lymphadenopathy, neck
Mild hepatosplenomegaly

Question 4

What are the key investigation of EBV infection?

Answer 4

FBC - elevated lymphocytes/thrombocytopenia
Monospot test - heterophile antibodies - 2nd week of illness
Throat PCR to rule out strep throat
EBV viral serology
Abdo ultrasound if spleenomegaly
HIV test

Question 5

What is the management for EBV?

Answer 5

Conservative - resolves within 2 to 4 weeks
Analgesia, fluids, rest, utrition

Question 6

What should be avoided whilst infected with EBV?

Answer 6

Alcohol
Ampicillin and amoxicillin -> trigger itchy maculopapular rash
Contact sports due to risk of splenic trauma

Question 7

What are some complications of EBV infectious mononucleosis?

Answer 7

Airway compromise from enlarged tonsils - ENT and steroids
Splenic rupture
Later life risk of lymphoproliferative conditions