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Flashcards in EBV Deck (19)
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1
Q

How does EBV initiate infections?

A

Infects cells of the respiratory system and regional lymph nodes

Then spreads to secondary sites via B-cell lineage lymphocytes

2
Q

Describe the structural characteristics of EBV

A

Double stranded DNA

Icosahedral capsid

Envelope with glycoprotein spikes

3
Q

What is the receptor molecule present on B cells that is utilized by EBV?

A

CD21

Also binds MHCII

4
Q

What are the primary viral antigens found in EBV infected cells?

A

EBNA - DNA binding proteins

VCA - capsid

MA - membrane

EA- early antigens

5
Q

Where does EBV establish latent infection?

A

Memory B cells when competent T cells are present

6
Q

Where does replication of EBV take place?

A

Permissive cells, resting B cells in the tonsils

7
Q

What is the function of gp350/220?

A

Glycoproteins that enable attachment of the virus to CD21

8
Q

What genes are expressed during a latent EBV infection?

A

EB Nuclear Antigen-1 and latent proteins

9
Q

What proteins are important for B cell immortalization during EBV infection?

A

Latent membrane proteins (3) - stimulate the replication of B cells

10
Q

What diseases is EBV associated with?

A

Mononucleosis

Burkitts lymphoma

Nasopharyngeal carcinoma

11
Q

What are the three primary symptoms of infectious mononucleosis?

A

Lyphadenopathy

Splenomegaly

Exudative pharyngitis

12
Q

What are heterophile antibodies?

A

Polyclonal antibodies (IgM) produced by infected B cells

Detected with monospot test (some patients can be negative)

13
Q

What are Downey cells?

A

Atypical T lymphoctyes that are large, basophilic, and have foamy cytoplasm

14
Q

What are the best lab tests for EBV?

A

Virus neutralization

Immunofluoresence

CF for viral antibodies

15
Q

What is the treatment for EBV?

A

Symptomatic management

Valacyclovir for severe infections

16
Q

What is chronic EBV mononucleosis?

A

Chronic systemic mono symptoms, fatigue most common

Last months to years

Women most likely affected

17
Q

What does HHV6B cause?

A

Exanthem subitum (roseola)

Infections B and T cells, can also infect neurons

Can reactivate in transplant patients

18
Q

What do HHV6 and 7 cause?

A

Roseola - high fever with rash that starts on trunk and face first then spreads

19
Q

What is associated with HHV8 infection?

A

Kaposi sarcoma - found among AIDS patients

Also rare type of B cell lymphoma