ECM

Question 1

jelly like; made up of electrolytes, polysaccharides, proteins
solid in cartilage and bone, liquid in blood

Answer 1

ground substance

Question 2

type of chain of carbs
negatively charged surfaces; attract cations like Na+
high fluid content makes material resistent to compression
linked to proetins

Answer 2

GAGs

Question 3

bing to GAG

up to 95% carbs by weight

Answer 3

proteoglycans

Question 4

proteins that contain carb chains

made of numerous short, branched ogliosaccharides

Answer 4

glycoproteins

Question 5

main ECM protein

flexible, but strong and resistent to stretch

Answer 5

collagen

Question 6

stretchy and flexible, main component of structures known as elastic fibers

Answer 6

elastin

Question 7

mechanical barrier
anchor for epithelium
molecular filler for epithelium

Answer 7

basement membrane

Question 8

main ECM adhesion protein in hemidesomsomes and focal contacts
2 types, alpha and beta

Answer 8

integrin

Question 9

ECM ligand binds to low affinity integrin and converts to high affinity

Answer 9

outside-in activation

Question 10

integrin beings to proteins inside the cell that convert it to high affinity

Answer 10

inside-out activation

Question 11

link to actin
can be composed of a variety of integrin heterodimers
critical for cell movement/migration

Answer 11

focal adhesions

Question 12

linked to IF’s
feature of epithelial cells
found on basal aspect of columnar cells in pseudostratified ep.

Answer 12

hemidesmosomes