ECM Proteins

Question 1

Name 4 main types of ECM proteins

Answer 1

1. Proteoglycans
2. Collagens
3. Multi adhesive matrix proteins
4. Elastic fibers

Question 2

Proteoglycans collagens and multi adhesive matrix pro are a part of what structure(s)

Answer 2

Both basal lamina and connective tissue BL and CT

Question 3

Which ECM protein type is Laminin?

Answer 3

Multi adhesive matrix protein

Question 4

What about Fibrilin?

Answer 4

Elastic fibers

Question 5

Describe Proteoglycan structure

Answer 5

Chondroitin sulfate repeats+ linking sugars+ Ser+ core protein
Resembles a brush; hyaluronic acid backbone

Question 6

What are the main features of proteoglycans?

Answer 6

Hydrated space filling gel
Resistance to compression
Space for cell migration

Question 7

What is the basal unit of collagen?

Answer 7

Triple coiled-coil helix

Question 8

Which protein will form homo and Herero- trimmers as their tertiary structure?

Answer 8

Collagen

Question 9

Collagen synthesis step 1-3

Answer 9

Intracellular stage in RER:
1. Synthesis of tripeptides GlyXY
2. Hydroxylation of X(pro) and Y(lys) + glycosidation of Lys-OH
3. Pro collagen trimer formation

Question 10

Collagen synthesis step 4-6

Answer 10

First moves to Golgi apparatus for lateral