ECM questions

Question 1

Which of the following diseases is not associated with faulty collagen?

Answer 1

Marfan Syndrome

Question 1

What maintains tissue homeostasis and bears the initial cellular insults in various disease states?

Answer 1

Extracellular Matrix

Question 2

All types of Muscular Dystrophy (MD) involve low or absent expression of the protein dystrophin.

Answer 2

False

Question 3

Excess formation of connective tissue in response to injury results in the damaging process known as:

Answer 3

Fibrosis

Question 4

Many types of heritable skin, bone and cartilagenous diseases can be attributed to defective Extracellular Matrix (ECM) components, particularly collagen.

Answer 4

True

Question 5

Intervertebral Disc disease

Answer 5

-is largely attributed to the loss of glycosaminoglycans, namely aggrecan, in aging IV discs.

• is characterized by decreased hydration, reduced compressibility and increased risk of disc herniation.
• may be compounded by hypoxia, inflammation, and autophagy.
• is one of the most common causes of back pain affecting nearly everyone at some point in his/her life.

Question 6

Aneurysms

Answer 6

• are a ballooning and loss of blood vessel wall integrity due to the breakdown of collagen and elastin.
• are most deadly when they occur in the aorta and the Circle of Willis in the brain.

Question 7

Which of the following matrix components does not interact with cell surface receptors to augment tumor growth?

Answer 7

endorepellin

Question 8

The structural aspects of the ECM are most important to understand when it comes to the development of new therapeutic agents for the treatment of diseases.

Answer 8

false

Question 9

Tumor vasculature has become an novel and effective target for curbing cancerous growth.

Answer 9

true.