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05. Andro (1569) > ED > Flashcards

ED Flashcards

1
Q

Men presenting with ED should undergo:

A

GUIDELINE STATMENT 1

A thorough medical, sexual, and psychosocial hx, a PE, and selective laboratory testing

risk factors include: age, comorbid medical and psych condition, prior sx, medication, fhx of vascular dz, personal hx vascular dz, substance abuse, tobacco, neuro dz, endocrinopathies, meds, psychosocial

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2
Q

What is recommended to quantify and qualify a man’s sxs with ED?

A

GUIDELINE STATEMENT 2

validated questionnaire

(bother, satisfaction, relationship impact)

IIEF, SHIM

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3
Q

What health concerns can ED be a warning sign of?

A

GUIDELINE STATEMENT 3

CVD

(endothelial dysfunction and inflammation)

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4
Q

What initial lab tests for ED should be performed?

A

GUIDELINE STATEMENT 4

testosterone

2 am values (do not measure during acute illness)

(< 300 ng/DL low)

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5
Q

What instances may warranted specialized testing? What does this testing include?

A

GUIDELINE STATEMENT 5

some men warrant specialized testing may guide treatment

young
have strong fhx CVD
hx of pelvic trauma
failed prior ED tx
strong likelihood of primary psychogenic
concomitant PD
lifelong ED

Tests:
**Nocturnal penile tumescence (shaft gauge during sleep)
**ICI (in office: prostaglandin E1, paparavine, and/or phentolamine)
**Penile duplex US (7-10 Hz transducer, 5-10 minutes after ICI → vascular eval: PSV < 30 → arterial insufficiency, EDV > 5 veno-occlusive dz; RI (EDV/PSV >0.80 → normal)
**Caversonometry (quantify pressure after ICI), selective internal pudendal angiography
**Pudendal arteriography (young men with suspected arterial insufficiency)

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6
Q

For ED, referral to whom after initial evaluation SHOULD be considered? How will this help?

A

GUIDELINE STATEMENT 6

Mental health professions

to promote treatment adherence, reduce performance anxiety, and integrate tx into sexual relationship

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7
Q

What should clinicians counsel men with ED about lifestyle?

A

GUIDELINE STATEMENT 7

comorbidities negatively affect ED

lifestyle modifications, including changes in diet, increased physical activity, will improve overall health and improve erectile function

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8
Q

What is an FDA approved initial treatment option for ED? What should be discussed?

A

GUIDELINE STATEMENT 8

PDE5i (phosphodiesterase type 5 inhibitor)

inhibit breakdown of cGMP → increase smooth muscle relaxation in corpus cavernosum → increased erection hardness

discuss benefits, risks, efficacy

contraindications: nitrates (hypotension), amyl nitrate (poppers) other interactions: antidepressants, anti-fungal, anti-hypertensives, HIV/AIDS drugs

*patients should be stable on alpha blocker prior to initiating PDE5i (some interaction for hypotension)

  1. PDE5i, particularly sildenafil, tadalafil, and vardenafil, appear to have similar efficacy for general population
  2. Dose-response effects across PDE5i meds are small and non-linear (i.e. doubling dose not double effect)
  3. On- demand dosing vs. daily for tadalafil appears to have same level of efficacy
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9
Q

Most common a/e of PDE5i

A

dyspepsia
headache
flushing
back pain
nasal congestion
myalgia
visual disturbance
dizziness

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10
Q

Detail instruction to maximize efficacy for PDE5i

A

GUIDELINE STATEMENT 9

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11
Q

Dosing of PDE5i should be:

A

GUIDELINE STATEMENT 10

titrated to provide optimal efficacy

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12
Q

Patients who try PDE5i without efficacy, what should be considered?

A

Incorrect usage
black market products
require sexual stimulation
waiting and adequate amount of time
fatty meals (sildenafil and vardenafil, tadalafil is unaffected by food)

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13
Q

How are PDE5i metabolized:

A

cytochrome CYP4A system

*dose reduction may be necessary with CYP450 i (ketoconazole, erythromycin, ritonavir, indinivir, grapefruit juice)

Others may enhance: rifampin, phenobarbital, phenytoin, carbamazepine

**Men with severe hepatic or renal dysfunction (GVR < 30) should be stared on lowest dose

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14
Q

How do you follow men on PDE5i

A

Recheck at 3 mo for BPH and efficacy/adverse effects

If satisfactory, q 6-12 mo for same

ask for changes in meds (nitrates, addition of alpha blocker, etc)

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15
Q

What should patients be informed about penile rehab after RP or RT?

A

GUIDELINE STATEMENT 11

men who desire preservation o f erectile function after treatment for prostate cancer by radical prostatectomy or radiotherapy should be informed that early use of PDE5i post-treatment may not improve spontaneous, unassisted erectile function

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16
Q

Men with ED and testosterone deficiency should be informed:

A

GUIDELINE STATEMENT 12

that PDE5i may be more effective if combined with testosterone therapy

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17
Q

In addition to medication therapy, what manual device should patients be informed of?

A

GUIDELINE STATEMENT 13

Vacuum erection device (VED)

*with vacuum limiter

including r/b and burdens

low cost, high degree of satisfaction

a/e: transient penile petechiae or bruising, discomfort or pain, difficulty with ejaculation, difficulty with device, loss of sensitivity

*caution with AC or bleeding disorders or hx of priapism

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18
Q

What intraurethral medication can be utilized?

A

GUIDELINE STATEMENT 14

Alprostadil (MUSE→PGE1)

GUIDELINE STATEMENT 15

an in-office test must be performed

100, 250, 500, 100 ug, 10-30 mins before intercourse

a/e: genital pain, minor urethra trauma, urethral pain/burning, dizziness, hypotension/syncope (rare), painful/prolonged erection (1%)

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19
Q

Contraindications to MUSE?

A

structural abnormalities such as urethral stricture, penile angulation/fibrosis, infections (balanitis/urethritis)

*condom must be used during sexual activity with pregnant women

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20
Q

Men should be informed of what injection therapy?

A

GUIDELINE STATEMENT 16

intracavernosal injections (ICI)

(alprostadil [FDA approved] urethral burning→ increases cGMP; phentolamine → alpha inhibitor inhibit detumescence; papaverine PDEi → together called Trimix [compounded])

GUIDELINE STATEMENT 17

in-office injection test should be performed

wipe with alcohol, inject dorsal 10:00 and 2:00, hold pressure 2-3 mins
pt to assess and self stimulate in office
can only leave when detumesced

a/e: priapism, pain with injection, penile pain, genital pain, penile fibrosis or plaque, and penile deformities

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21
Q

What surgical options should men be informed of?

A

GUIDELINE STATEMENT 18

penile prosthesis implantation

malleable or inflatable

risks: risks of procedure, changes in penile appearance, potential for malfunction/failure, irreversible

a/e: penile edema/hematoma, corpus injury, urethral injury, acute urinary retention, crura injury, infection, erosion, mechanical failure

GUIDELINE STATEMENT 19

patients should be counseled on post-op expectations

(not full rigidity, no effect on libido, pain, penile length, girth, sensation

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22
Q

Penile prosthetic surgery should not be performed in presence of:

A

GUIDELINE STATEMENT 20

systemic, cutaneous, or UTI

(for sx vanco or first/second gen cephalosporin + aminoglycoside 1 h prior to sx–only in absence of infection)

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23
Q

Name 3 (2 popular) approaches to implanting penile prosthesis and advantages/disadvantages:

A

Key: shave at sx, thorough skin prep, Abx
Aminoglycoside + 1st/2nd Gen Cephalosporin or Vanc

  1. Penoscrotal
    1. Proximal corporotomies, cylinder tubing less palpable
    2. along ventrum of corpora
    3. direct visualization of pump placement
    4. disadvantage: reservoir placed blind through perforation of inguinal canal to place retropubic
  2. Infrapubic
    1. allow direct visualization of reservoir placement
    2. pump can be more challenging, dorsal nerves are more at risk, cylinder tubing is more likely to be palpable
  3. Sub-coronal for malleable
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24
Q

Intraoperative complications of penile implant?

A
  1. Urethral perforation: blood at meatus, stop, leave cath 7-10 d
  2. Corporal crossover: when dilating corpora if septum perforated, leave dilator in side cross over into, re-dilate the side cross over originated from
  3. Crus perforation: during proximal dilation, create mesh wind sock to buttress rear tip and secure to tunica, secure rear tip itself to tunica albuginea, close corpora around tunica
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25
Post op ST and LT complications of penile implant?
1. Infection (1-3%): early with fever, pain swelling, purulence (usually G+); late with chronic pain or skin fixation, elevated WBC or ESR; MUST REMOVE 2. Malfunction (15-20% @ 10y): replacement of device or part 3. Erosion: mc in DMII or lack sensation (paraplegia) or malleable → remove eroded cylinder and replace or leave and utilize one cylinder 4. SST (poor glans support): insufficient distal dilation, small cylinders; remove and re-dilate, but can do glans plication to penile shaft also 5. Buckling or S-shaped deformities: oversized cylinder; replace cylinders 6. Auto-inflation: activity inflates device: replace device with lockout mechanism
26
For infected IPP, what are options for mgmt?
Remove and salvage (washout, abx) replace: success 80% Remove and delay replacement, can be challenging due to corporal fibrosis, shortened length (6-12 weeks)
27
For young men with ED and focal pelvic/penile arterial occlusion what are parameters considered and what type of intervention can be considered?
GUIDELINE STATEMENT 21 without documented generalized vascular dz or veno-occlusive dysfunction → penile arterial reconstruction GUIDELINE STATEMENT 22 for ED, penile venous surgery is not recommended
28
What treatments are considered investigational for ED?
GUIDELINE STATEMENT 23 low-intensity extracorporeal shock wave therapy (ESWT) GUIDELINE STATEMENT 24 intracavernosal stem cell therapy GUIDELINE STATEMENT 25 platelet-rich plasma (PRP)
29
Describe the relevant nerves of the penis:
Sensory: dorsal nerves via the pudendal nerve Sympathetic nerves (T10-L2): superior and inferior hypogastric pelvic plexus, cavernous nerves (NE → maintain flaccidity and detumescence) Parasympathetic nerves (S2-3): pelvic plexus cavernous nerves (release NO → erections)
30
Describe physiology of an erection:
Cavernosal artery smooth muscle relaxation During stimulation → parasympathetic nerves release NO → increase cGMP → relaxes cavernosal smooth muscle Arterial dilation → increased arterial inflow → expansion of lacunar spaces Dilation compresses penile venous outflow (sub-tunical venules and emissary veins that transverse tunica albuginea) Detumescence → release of NE from sympathetics → vasoconstriction → decreased arterial inflow and increased venous outflow
31
Key components of sexual history:
Personal: gender identity, sexual orientation, age of partner(s), relationship status, relationship duration, frequency of sexual activity Sexual dysfunction: severity, onset, rate of decline, nocturnal erections, ability to sustain erection, exacerbating or alleviating factor, previous tx, degree of distress, goal of tx Social: job, stress level, life changes, health changes associated with timing
32
Evaluations and Lab tests can be considered if concerned about comorbidities affecting ED?
BP Exercise tolerance CV risk assessment (High risk (uncontrolled HTN, untreated, uncontrolled conditions, severe CHF) → cardio clearance Lipid profile fasting glucose or HbA1c testosterone (guideline recommended) CBC (anemia) BMP (renal failure) Optional: tailored to patients complaints/risks TSH Prl PSA
33
3 classifications of ED?
Organic: vasculogenic (arterial or veno-occlusive), neurogenic, endocrinologic, meds Psychogenic Mixed
34
Good questions to ask when initially evaluated patient with ED complaints:
Does he ejaculate, if so, pain or blood? How man sexual partners, STDs? Morning erections, nocturnal erections, masturbation, spontaneous? Libido? How long has ED been a problem? Is he active, job, exercise? How far/fast can he walk, leg cramp? How much of problem for him and partner?
35
Important physical exam elements?
Gross neuro General appearance, weight, vitals Abdomen External genitalia DRE Pulses, extremities
36
Antihypertensive that affect ED? Antihypertensive safe for ED?
Adverse: Thiazide, Beta blockers Safe: Ca antagonists, ACE, ARBs
37
Arterial supply of penis
pudendal artery –> common penile artery -> superficial dorsal artery and deep cavernosal artery
38
Penile innervation
Parasympathetic (S2-4)
39
ED risk factors
``` Vascular Disease Diabetes Medications Neurogenic Pelvic surgery/radiation Endocrine ```
40
Medications associated with ED Cardiac - ____ Psych - ____ Urologic - ____
CCBs, Beta blockers, Digoxin, Diuretics SSRIs, Benzos ADT, Finasteride
41
PDE5-is promote erections by inhibiting breakdown of ___ to ___
cGMP --> GMP
42
____ catalyzes guanyl cyclase to synthesis GMP --> cGMP to promote smooth muscle relaxation & erectile function
NO
43
Levitra & viagra must be taken ____ eating
before eating on an empty stomach *no food effect for Cialis*
44
Onset of Viagra is ___ minutes Onset of Cialis is ____ minutes
Viagra = 60 min Cialis = 120 min
45
Contraindications to PDE5is
Poor cardiac function | Nitrates
46
PDE-5i side effects
``` Facial flushing GI effects (Heartburn) Nasal congestion Visual disturbances (diplopia, changing colors) Myalgia ```
47
What are the 3 drugs in trimix and their mechanisms of action?
PGE1: cAMP activator Papaverine: non‐specific PDE inhibitor Phentolamine: alpha blocker
48
Trimix side effects
Pain from PGE1 Bruising Priapism
49
Mechanism of intraurethral MUSE
PGE-1
50
Side effects of MUSE
``` Priapism Urethral bleeding Penile pain (PGE1 hypersensitivity) Inconsistent response Vaginal irritation ```
51
Vacuum device contraindications
Poor penile sensation (SCI) Poor cognitive function Peyronie’s Anti-coagulation
52
IPP has a ___% infection risk
3%
53
IPP has a ___% device failure rate at 10 years
20%
54
During IPP placement, procedure must be aborted if ___ perforation occurs
urethral
55
What are the common risk factors that should be asked about during the workup of ED
Common risk factors for ED include vascular disease, tobacco use, neurologic disease, endocrinopathies, medication-related side effects, and psychosocial issues.
56
What should the physical exam focus on during the workup of ED?
Blood pressure BMI Secondary sex characteristics Genital exam.
57
What are the validated questionaires for ED?
Erection hardness score (EHS) Sexual health inventory for Men (SHIM) International index of erectile function (IIEF) Male sexual health questionaire.
58
What should every physician counsel patients on when managing their ED?
Association with CVD. 25% increased risk of CVD when someone has ED.
59
What is the definition of testosterone deficiency?
Testosterone <300ng/dl | with signs and symptoms
60
What is the recommended lab testing for men with ED according to AUA guidelines?
Morning testosterone. | At least two morning testosterone values if abnormal for confirmation.
61
What are the indications for specialized evaluations for ED?
``` 1 Young 2 Family history of CVD 3 Pelvic trauma 4 Failure of previous ED therapies 5 Liklihood of psychogenic etiology 6 Lifelong ED 7 Peyronies disease ```
62
How can psychogenic ED be differentiated?
Nocturnal penile tumescence and rigidity testing.
63
How can penile vascular function be evaluated?
In office ICI or penile duplex ultrasound (gold standard)
64
How is penile duplex ultrasound interpreted?
PSV < 30 indicates arterial insufficiency EDV > 5cm/s indicates veno-occlusive dysfunction. Resistive index (PSV-EDV/PSV) <0.80 is normal veno occlusive function
65
What 2nd/3rd line diagnostics for vascular function are available?
Cavernosometry
66
How is cavernosometry interpreted?
Intracorporeal pressure of >60mmHg Pressure to maintain errection <35ml/min <45mmHg/30sec pressure decay brachial artery inflow gradient <30mmHg
67
What should be offered along with any treatment for ED?
Mental health referral
68
What should be the first management recommendation for ED per the AUA guidelines?
Behavioral modification such as diet or exercise for reversible comorbidities.
69
What is the first line treatment for ED per the AUA guidelines?
Phosphodiesterase inhibitors
70
What is the MOA for PDE5i?
PDE5i inhibit the phosphodiesterase type 5 enzyme from breaking down cyclic guanasine monophosphate (cGMP). This inhibition results in an increase in the concentration of penile cavernosal cGMP that then causes smooth muscle relaxation in the corpus cavernosum vasculature resulting in increased erection hardness and duration
71
What are the contraindications to PDE5i use?
1. Nitrate containing medications. 2. Hepatic impairment (use with caution) 3. Renal impairment (use with caution)

05. Andro (1569) (16 decks)

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