Edoxaban

Question 1

What is the recommended dose of edoxaban?

Answer 1

60mg OD

Question 2

When would you reduce the dose to 30mg OD?

Answer 2

If one or more of the following are present:

• Moderate or severe renal impairment (creatinine clearance [CrCL] 15–50 mL/min).
• Body weight of 60 kg or less.
• The person is receiving concomitant treatment with any of following P-glycoprotein (P-gp) inhibitors: ciclosporin, dronedarone, erythromycin, or ketoconazole.

Question 3

How would you switch from edoxaban to warfarin?

Answer 3

• For people taking 60 mg of edoxaban, prescribe 30 mg once daily with warfarin.
• For people taking 30 mg of edoxaban, prescribe 15 mg once daily with warfarin.

Question 4

What would you monitor prior to starting edoxaban?

Answer 4

• Body weight
• Renal function (U&Es, calculated CrCl)
• Baseline Clotting Screen
• Full blood count
• LFTs
• BP

Question 5

What would ongoing monitoring for edoxaban be?

Answer 5

• U&Es, CrCl, LFTs, FBC

6 monthly for people over 75

Question 6

What if you miss a dose of edoxaban?

Answer 6

• can be taken up to 12 hours prior to when next dose is due