Effector Mechanisms Flashcards

1
Q

When cAMP increases in the cell, what happens to PKA?

A

Dissociation of regulatory and catalytic subunits

Catalytic subunit activated - free to phosphorylate substrates

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What can activate PKC?

A

DAG

Ca2+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the 2 subunits of PKA?

A

R - regulatory

C - catalytic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is a postive inotropic effect?

A

Increasing the force of contraction of the heart

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Which ligand and receptor has a positive inotropic effect?

A

Adrenaline/NA

Beta 1 adrenoceptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Increasing intracellular calcium into the heart increases…

A

Contractility

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

All smooth muscle contraction utilises which G protein?

A

G alpha q

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

How does morphine prevent neurotransmitter release?

A

Activates G alpha i proteins
The beta-gamma subunit binds to VOCC
Inhibits the channels so it is harder for Ca2+ to enter the cell therefore less stimulus for neurotransmitter release

How well did you know this?
1
Not at all
2
3
4
5
Perfectly