Effector mechanisms Of T Cell Mediated Immunity Flashcards
IL-2 source and principal action
Activated T cells
T cell proliferation
Regulatory T cell survival
IFN-gamma source and principal action
CD4+, CD8+, NK Cells
Activate macrophages
IL-4 source and principal action
CD4+ and mast cells
B cell switching to IgE
IL-5 source and principal action
CD4+, mast cells, innate lymphoid cells
Activate eosinophils
IL-17 source and principal action
CD4+ and other cells
Stimulate acute inflammation
IL-22 source and principal action
CD4+, NK cells, innate lymphoid cells
Maintain epithelial barrier
TGF-beta source and principal action
CD4+, many other cells
Inhibit T cell activation
Promote regulatory T cell differentiation
What is the Macrophage response to activation via Th1 cell?
Production of ROS, NO, and lysosomal enzymes
[for killing microbes]
Secretion of cytokines (TNF, IL-1, IL-12) and chemokines
[TNF, IL-1 for leukocyte recruitment {inflammation}; IL-12 for Th1 differentiation and IFN-gamma production]
Increased expression of B7 costimulators, and MHC molecules
[for increasing T cell activation]
What chromosome is the cd40L gene found on?
X chromosome
Mycobacteria resistance of immunity
Inhibits the fusion of phagosome and lysosome (phagolysosome)
Herpes Simplex Virus (HSV) resistance of immunity
Inhibits AG presentation by interfering with TAP transporter in ER
Cytomegalovirus resistance of immunity
Inhibits AG bonding by inhibiting proteosomal activity (breakdown of foreign proteins for Ag presentation) AND inhibits removal of MHC class I molecules from ER
Epstein-Barr Virus resistance of immunity
Inhibits Ag presentation by inhibiting proteosomal activity (breakdown of foreign proteins for Ag presentation) AND ALSO secretes IL-10 which inhibits Macrophage and DC activation
Pox Virus resistance of immunity
Inhibits effector Cell activation by producing soluble cytokines receptors (blocking cytokines activation of effector cells)
