Eicasanoids drugs

Question 1

Dinoprostone is a _____ analogue

Answer 1

PGE2

Question 2

Activation of collagenase [breakdown of collagen], also relaxes cervical smooth muscle

Answer 2

Dinoprostone

Question 3

Causes cervical ripening in pregnancy

Answer 3

Dinoprostone

Question 4

Zileuton works by:

Answer 4

inhibitor of 5-lipoxygenase

Question 5

Mechanism of Zileuton

Answer 5

inhibits cys-LTs (bronchoconstriction and
increase vascular permeability and LTB4
(chemotaxis)

Question 6

Administration of Zileuton

Answer 6

Oral with half life of 2.5 hours

Question 7

Pharmakokinetics of Zileuton

Answer 7

metabolized by CYPs

Question 8

Use of Zileuton

Answer 8

prophylaxis tx of asthma

Question 9

cysteinyl leukotriene receptor antagonists

Answer 9

Zafirlukast

Question 10

inhibits cys-LTs (bronchoconstriction and
increase vascular permeability and LTB4
(chemotaxis)

Answer 10

Zileuton

Question 11

What drug inhibits 5-lipoxygenase

Answer 11

Zileuton

Question 12

Metabolism of Zarfirlukast

Answer 12

CYP2C9

Question 13

Zarfirlukast works by:

Answer 13

inhibitiing cys-leukotriene receptor

Question 14

Uses of Zarfirlukast

Answer 14

prophylaxsis of mild asthma

Question 15

Two uses of Dinoprostone

Answer 15

cervical ripening in pregnancy

abortion on early pregnancy

Question 16

Mechanism of action for Dinoprostone for abortion:

Answer 16

uterine contractions via EP1/3 receptors

Question 17

What happens when Dinoprostone acts on EP4 receptor?

Answer 17

promotes cervical ripening, also relaxes cervical smooth muscle

Question 18

When Dinoprostone acts on EP1/3 receptor, what is it doing?

Answer 18

causing uterine contractions for an abortion

Question 19

GI-Related (nausea, vomiting, diarrhea)
fever
uterine rupture: contraindicated in women having
history of cesarean section or other uterine surgery

Answer 19

Dinoprostone

Question 20

Women who’ve had cesarean section or other urterine surgiers shouldn’t use:

Answer 20

Dinoprostone

Question 21

Carboprost is what kind of PG analogue

Answer 21

PGF2alpha

Question 22

uses of Carboprost

Answer 22

2nd trimester aboriton

to control hemorrhage after delivery

Question 23

How does Carboprost cause an abortion?

Answer 23

stimulates uterine contractility by action at FP

receptors

Question 24

This drug stimulates uterine contractility by action of The FP receptors

Answer 24

Carbaprost

Question 25

the drug causes myometrial contractions via FP receptors. This provide hemostasis at the site of placenta formation.

Answer 25

Carbaprost

Question 26

Carbaprost will stop bleeding by:

Answer 26

causing myometrial conx via FP receptors

Question 27

Contraindications of Carbaprost

Answer 27

GI-Related (nausea, vomiting, diarrhea) fever uterine rupture: past cesearan or uterine surgery

Question 28

What two drugs should you not use if you've had cesarea

Answer 28

Carboprost and Dinoprostone

Question 29

Misoprostol is what kind of analgue

Answer 29

PGE1 analogue

Question 30

Uses of MIsoprostol

Answer 30

primarily used as “replacement therapy” for prevention of ulcers caused by long-term administration with NSAIDs

Question 31

primarily used as “replacement therapy” for prevention of ulcers caused by long-term administration with NSAIDs

Answer 31

Misoprostol

Question 32

Mechanism of Misoprostol | --what receptor does it act on?

Answer 32

suppresses gastric acid secretion by stimulating EP3 receptors on parietal cells; causes a decrease in cAMP increase mucin and bicarbonate secretion increase mucosal blood flow

Question 33

Adverse affect with Misoprostol

Answer 33

diarrhrea--commone

Question 34

Contraindicationof Misoprostol

Answer 34

pregancy

Question 35

Alprostadil is an analogue for

Answer 35

PGE1

Question 36

Uses for Alprostadil: 2 of them

Answer 36

ED | maintain patent ductus arteriosis

Question 37

increase in cAMP which relaxes smooth | muscle of corpus cavernosum

Answer 37

Alprostadil

Question 38

MEch of Alprostadil (ED)

Answer 38

increases cAMP--> relaxes smooth muscles of corpus cavernosum

Question 39

Mech of Alprostadil for patent ductus arteriosis

Answer 39

cAMP-mediated relaxation of ductus | arteriosus smooth muscle

Question 40

cAMP-mediated relaxation of ductus | arteriosus smooth muscle

Answer 40

Alprostadil

Question 41

side effect seen in neonates given Alprostadil

Answer 41

apnea

Question 42

Epoprostenol is what kind of analogue

Answer 42

PGI2 analogue

Question 43

primary pulmonary hypertension rare, idiopathic disease mainly observed in young adults; increased incidence in females leads to right heart failure; frequently fatal;

Answer 43

Epoprostenol

Question 44

Epoprostenol is used for what?

Answer 44

tx pulmonary hypertension--rare, seen in femalse, can lead to Right heart Fail

Question 45

Mech of action of Epoprostenol?

Answer 45

cAMP-mediated dilation of pulmonary | artery vascular smooth muscle

Question 46

Adverse effects seen with Epoprostenol

Answer 46

nausea, vomiting, headache, flushing

Question 47

Bimatoprost is analogue for

Answer 47

PGF2alpha

Question 48

two uses of Bimatoprost

Answer 48

eyelashes | glaucoma

Question 49

How does Bimatoprost tx glaucoma?

Answer 49

increaes outflow of aqueous humor

Question 50

How does Bimatoprost increase eyelashes

Answer 50

increases length and duration eyelashes are in growth phase

Question 51

PGF2alpha agonists

Answer 51

Bimatoprost

Question 52

Side effect of Bimatoprost

Answer 52

excess, unwanted hair growth, brown iris | pigmentation, eye redness, itching