Eicosanoides Flashcards

1
Q

De dónde derivan los eicosanoides

A

Ácidos grasos de 20C
Ácido araquidónico

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2
Q

Precursor del ácido iónico

A

Ácido linoleico, linoleato

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3
Q

Dónde encontramos ácido araquidónico

A

En los fosfolípidos de la membrana

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4
Q

Quién libera el ácido araquidonico de la membrana?

A

Fosfolipasa A2 o C

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5
Q

Tipos de vidas de síntesis de los eicosanoides

A

Vía cíclica
Vía lineal
Citocromo p450

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6
Q

Qué es se produce la vía cíclica

A

Prostaglandinas
Tromboxanos

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7
Q

Enzima de la vía cíclica

A

Ciclooxigenasa

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8
Q

Inhibidor de la COX de manera irreversible

A

Aspirina

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9
Q

Inhibidor de la COX de manera reversible

A

Ibuprofeno AINE

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10
Q

Tipos de ciclooxigenasa

A

COX 1
COX 2

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11
Q

COX 1

A

Constitutiva

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12
Q

Fx COX 1

A

Producción de prostaglandinas y tromboxanos normalmente

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13
Q

COX 2

A

Inducible

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14
Q

Cuándo está presente la COX 2

A

En tejidos inflamados, excepto en cerebro y riñones = constitutiva

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15
Q

Productos de la vía lineal

A

Leucotienos

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16
Q

Enzima de la vía lineal

A

Lipooxigenasa

17
Q

Productos del Cit p450

A

Epóxidos