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Y2C1 ergül > Eicosanoids and related compounds > Flashcards

Eicosanoids and related compounds Flashcards

Y2C1 2 questions will be asked (68 cards)

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1
Q

Steroid drugs blocks release of_____acid from plasma membrane

A

aranchidonic acid

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2
Q

Eicosanoids origins from____acid

A

Aranchidonic acid

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3
Q

Most 2 important enzymes on syntesis of eicosanoids are ?

A

cyclooxygenase & lipoxygenase

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4
Q

Cycloxygenase converts arachidonic acid to______&_____ and______

A

prostaglandins & prostacyclins and thromboxanes

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5
Q

_______ enzyme is responsible for Prostaglandins, thromboxanes and prostagcylins synthesis

A

cyclooxygenase

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6
Q

___genase converts aranchidonic acid into hydroxy fatty acids and leukotriens

A

lipoxygenase

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7
Q

lipoxygenase synthesises_____&_____from aranchidonic acid

A

leukotriens and hydroxy fatty acids

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8
Q

Local hormones synthesized from________fatty acid known as_________

A

polyunsaturated
aranchidonic acid

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9
Q

Arachidonates has specific effects on target cells close to their site of________

A

formation

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10
Q

Arachidonates are rapidly_____

A

degraded

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11
Q

Arachidonates are not transported to_______sites within the body

A

distal sites

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12
Q

4 types of arachidonate exists which are?

A

Prostaglandins
Thromboxanes
Prostacylins
Leukotriens

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13
Q

All prostaglandins have a_____ring

A

cyclopentane ring

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14
Q

Letter code is based on______modifications

A

ring

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15
Q

Subscript refers to number of_____bonds in____side chains

A

double bonds in 2 side-chains

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16
Q

Prostaglandins biologically derived from____fatty acids, in particular arachidonic acid

A

essential C-20

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17
Q

3 major class of prostaglandins ?

A

A, E and F series

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18
Q

example for E type prostaglandin is_____ketone

A

b-hydroxyketone

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19
Q

example for F type prostaglandin is____

A

1,3 diols

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20
Q

example for A type prostaglandin is_______ketone

A

a-b unsaturated ketone

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21
Q

Functional group in____ring is different

A

cyclopentane ring

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22
Q

Subcript a or b refers to configuration of___group

A

C-9 OH group

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23
Q

what is the name of this open compound formula ?

A

PGF2a

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24
Q

Arachidonate released directly from_____phospholipid, catalyzed by_________

A

membrane
phospolipase A2

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25
Another way of arachidonate release is______catalyzed by_____kinase
diacylglycerol diacylglycerol kinase
26
______synthase catalyses comitted step in cyclic pathway
prostaglandin H2 synthase
27
_____,______&_____ are synthesized by cyclic pathway
prostaglandins, prostacyclins & thromboxanes
28
____synthase is heme-containing dioxygenase, bound to ER membranes
PGH2 synthase
29
PGH2 synthase ____ containing ____genase Bound to_____membranes
heme dioxygenase endoplasmic reticulum
30
Dioxygenase incorporates__ into a substrate
O2
31
PGH2 exhibits 2 activities ____genase &____dase
cyclooxygenase & peroxidase
32
PGH2 is sometimes referred to as____xygenase abbreviated___
cyclooxygenase abbreviated COX
33
1st step of linear pathway for synthesis of leukotrienes is catalyzed by ____
lipoxygenase
34
Aranchidonate converted into leukotrienes in___pathway
linear pathway
35
arachidonate converted into prostaglandin H2 via___pathway
cyclic
36
arachidonate into______with cyclic pathway
Prostaglandin H2
37
5-lipoxygenase found in___
leukocytes
38
5-lipoxygenase catalyzed conversation of arachidonate to_____
5-HPETE(5- hydroperoxy-eicosatetraenoic acid)
39
5-HPETE(5- hydroperoxy-eicosatetraenoic acid) converted to______
leukotriene-A4
40
Leukotriene-A4 can be converted to various other___
leukotrienes
41
Arachidonic acid can be converted into______&________,_______,______
prostacylin, leukotriene C4, DHETs, HETEs
42
g-protein is______receptor
cytoplasmic
43
PPARg is______receptor
nuclear
44
4 types of prostaglandin receptors exist
EP1 EP2 EP3 EP4
45
Prostaglandins use______receptors
G-protein receptors
46
Leukotriene use_____pathway
linear
47
Some leukotrinenes act via specific______receptors
G-prrtein coupled receptors(GPCRs)
48
5-lipoxygenase requires membrane protein_____
FLAP
49
FLAP binds______faciliating its interaction with enzyme
arachidonate
50
Corticosteroids are anti-inflammatory because they prevent___________expression which reduces arachidonate release
inducible phospholipase A2
51
İnducible phospholipase A2 expression reduces_____release
arachidonate
52
İbuprofen, aspirin and its derivatives inhibits cyclooxygenase activity of_____synthase
PGH2
53
____genase activity of PGH2 synthase is inhibited by ibuprofen and aspirin derivatives
cyclooxygenase
54
Non-steroidal anti-inflammatory drugs(NSAIDs) such as ibuprofen and aspirin and its derivatives inhibits blood clotting by blocking______formation in blood platelets
thromboxane
55
Ibuprofen and related compounds block_____channel by which arachidonate enters cyclooxygenase active site
hydrophobic channel
56
Arachidonate enters cyclooxygenase active site by____channel
cyclooxygenase active channel
57
which Cox levels increase in inflammatory diseases such as arthritis ?
COX-2
58
_____,_____,_____ increases COX-2 activity
cytokines IL-1, TNF, growth factors
59
______,_______ reduces COX-2 activity
glucocorticoids and cytokines IL-4
60
COX-1 plays role in____functions
homeostatic
61
COX-2 plays role in______
Inflammation
62
PGD2 is weak inhibitor of_____aggregation
platelet
63
PGE1 has role on_____vasodilation
bronchial
64
PGE2 has impo role on______and______vasodilation
renal and bronchial
65
PGF2 -stimulates ______smooth muscle relaxation -_____constrictor
uterine smooth muscle bronchial
66
PGI2 is potent inhibitor of______aggregation
platelet
67
LTB4 Increases_____ chemotaxis & aggregation
leucocyte
68
LTC/D4 -slow reacting substance of____ -_____construction
anaflaxis broncho

Y2C1 ergül (1 decks)

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