Eicosanoids & Cannabinoid Flashcards
Arachidonic Acid
Made from phospholipids by Phospholipase A2
Prostanoids
Formed from Arachidonic Acid
Eicosanoids that play an important role in inflammation
COX-1
Constitutive
Converts AA into Prostanoid
COX-2
Inducible
Converts AA into Prostanoid
NSAIDS
Non Selective Cox Inhibitor
PGH2
Precursor Prostaglandin
Prostacyclin (PGI2)
Converted by Prostacyclin Synthase in Endothelium
Inhibits Platelet Aggregation
Vasodilator
Thromboxane (TXA2)
Converted by Thromboxane Synthase in Platelets
Stimulates Platelet Aggregation
Vasoconstrictor
PGD2
Vasodilation
Inhibits Platelet Aggregation
Relaxes GI and Uterus Muscles
PGE2
Main Inflammatory Prostanoid
Vasodilator
PGF2a
Uterine Contraction
Alprostadil
PGE1
Vasodilation
Misoprostol
PGE2
Inhibits Gastric Acid Secretion
Increases GI Muscous Secretion
Uterine Contractions (Terminate Early Pregnancy)
Cervical Ripening/Dilation (Induce Labour)
Gemeprost
Uterine Contractions (Terminate Early Pregnancy)
Dinoprostone
PGE2
Cervical Ripening/Dilation (Induce Labour)
Carboprost
PGF2a
Uterine Contraction (Uses Blood to Cause)
Latanoprost
PGF2alpha
Uterine Contraction
Reduces Intraocular Pressure Eye (Tx Glaucoma)
Epoprostenol
PGI2
Inhibits Platelet Aggregation
Vasodilation (Treats Hypertension)
LTB4
BLT Receptor Agonist
Pro-Inflammatory Leukotriene
Stimulates Neutrophil Chemotaxis
Stimulates Proliferation
Stimulates Cytokine production
Cysteinyl Leukotriene
CysLT Receptor Agonist
Contracts Bronchi Muscle
Vasodilation
Constriction in Cornea
Zafirlukast
CysLT Receptor Antagonist
Treats Asthma (Inhibit Bronchoconstriction)
Montelukast
CysLT Receptor Antagonist
Treats Asthma (Inhibit Bronchoconstriction)
THC
Tetrahydrocannabinol
Psychoactive Compound in Cannabis
Vasodilation & Decreased Eye Pressure
Bronchodilation
Increased Appetite
More Sensory Awareness
Relaxation
Impaired Memory
Impaired Motor
CBD
Cannabidiol
Non psychoactive compound in Cannabis
